| Autor: |
Berdiaki A; Department of Histology-Embryology, Medical School, University of Crete, 712 03 Heraklion, Greece., Neagu M; Immunology Department, 'Victor Babes' National Institute of Pathology, 050096 Bucharest, Romania., Tzanakakis P; Department of Histology-Embryology, Medical School, University of Crete, 712 03 Heraklion, Greece., Spyridaki I; Department of Histology-Embryology, Medical School, University of Crete, 712 03 Heraklion, Greece., Pérez S; Centre de Recherche sur les Macromolécules Végétales (CERMAV), Centre National de la Recherche Scientifique (CNRS), University Grenoble Alpes, 38000 Grenoble, France., Nikitovic D; Department of Histology-Embryology, Medical School, University of Crete, 712 03 Heraklion, Greece. |
| Abstrakt: |
Glycosaminoglycans (GAGs) and proteoglycans (PGs) are essential components of the extracellular matrix (ECM) with pivotal roles in cellular mechanosensing pathways. GAGs, such as heparan sulfate (HS) and chondroitin sulfate (CS), interact with various cell surface receptors, including integrins and receptor tyrosine kinases, to modulate cellular responses to mechanical stimuli. PGs, comprising a core protein with covalently attached GAG chains, serve as dynamic regulators of tissue mechanics and cell behavior, thereby playing a crucial role in maintaining tissue homeostasis. Dysregulation of GAG/PG-mediated mechanosensing pathways is implicated in numerous pathological conditions, including cancer and inflammation. Understanding the intricate mechanisms by which GAGs and PGs modulate cellular responses to mechanical forces holds promise for developing novel therapeutic strategies targeting mechanotransduction pathways in disease. This comprehensive overview underscores the importance of GAGs and PGs as key mediators of mechanosensing in maintaining tissue homeostasis and their potential as therapeutic targets for mitigating mechano-driven pathologies, focusing on cancer and inflammation. |
