Synthesis and Biological Profiling of Seven Heparin and Heparan Sulphate Analogue Trisaccharides.

Autor: Demeter F; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary., Peleskei Z; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary., Kútvölgyi K; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary., Rusznyák Á; Department of Molecular and Nanopharmaceutics, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, Hungary.; Institute of Healthcare Industry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary., Fenyvesi F; Department of Molecular and Nanopharmaceutics, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, Hungary., Kajtár R; Department of Pharmacodynamics, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, Hungary., Sipos É; Department of Pharmacodynamics, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, Hungary., Lekli I; Department of Pharmacodynamics, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, Hungary., Molnár P; Department of Immunology, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary., Szöllősi AG; Department of Immunology, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary., Lisztes E; Department of Physiology, University of Debrecen, P.O. Box 22, H-4012 Debrecen, Hungary., Tóth BI; Department of Physiology, University of Debrecen, P.O. Box 22, H-4012 Debrecen, Hungary.; Department of Physiology, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary., Borbás A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.; HUN-REN-DE Molecular Recognition and Interaction Research Group, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary., Herczeg M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.; HUN-REN-DE Molecular Recognition and Interaction Research Group, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.
Jazyk: angličtina
Zdroj: Biomolecules [Biomolecules] 2024 Aug 25; Vol. 14 (9). Date of Electronic Publication: 2024 Aug 25.
DOI: 10.3390/biom14091052
Abstrakt: Researchers are paying increasing attention to the strongly negatively charged heteropolysaccharides in cells, in the extracellular matrix or in the cell wall. Examples of such molecules are glycosaminoglycans (e.g., heparin, heparan sulphate). It is well known from the literature that heparin and its derivatives have anti-inflammatory, angiogenic, metastatic and growth factor inhibitory activity. Herein, we present the efficient synthesis of six non-glycosaminoglycan (Glc-GlcA-Glc-sequenced) and one heparin-related (GlcN-GlcA-Glc-sequenced) trisaccharides with various functional group patterns. The anti-inflammatory, antioxidant and cell growth-inhibitory/cytotoxic effects of the synthesized compounds were tested. Among the investigated molecules, we have found some derivatives with a promising anti-inflammatory and antioxidant effect.
Databáze: MEDLINE
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