| Autor: |
Grazioli G; Department of Dental Materials, School of Dentistry, Universidad de la República, Av. General Las Heras 1925, Montevideo 11300, Uruguay., de León Cáceres E; Department of Dental Materials, School of Dentistry, Universidad de la República, Av. General Las Heras 1925, Montevideo 11300, Uruguay., Tessore R; Department of Dental Materials, School of Dentistry, Universidad de la República, Av. General Las Heras 1925, Montevideo 11300, Uruguay., Lund RG; Department of Restorative Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas 96010-610, Brazil., Monjarás-Ávila AJ; Dental Materials Laboratory, Academic Area of Dentistry, Autonomous University of Hidalgo State, San Agustín Tlaxiaca 42160, Mexico., Lukomska-Szymanska M; Department of General Dentistry, Medical University of Lodz, 92-213 Lodz, Poland., Hardan L; Department of Restorative Dentistry, School of Dentistry, Saint-Joseph University, Beirut 1107 2180, Lebanon.; Department of Digital Dentistry, AI and Evolving Technologies, Saint-Joseph University, Beirut 1107 2180, Lebanon., Bourgi R; Department of Restorative Dentistry, School of Dentistry, Saint-Joseph University, Beirut 1107 2180, Lebanon.; Department of Biomaterials and Bioengineering, INSERM UMR_S 1121, University of Strasbourg, 67000 Strasbourg, France., Cuevas-Suárez CE; Department of General Dentistry, Medical University of Lodz, 92-213 Lodz, Poland. |
| Abstrakt: |
This systematic review aims to evaluate whether the application of antioxidant solutions can enhance the bond strength of resin-based materials to sodium hypochlorite (NaOCl)-treated dentin. This study follows the PICOT strategy: population (sodium hypochlorite-treated dentin), intervention (application of antioxidants), control (distilled water), outcome (bond strength), and type of studies (in vitro studies). The systematic review and meta-analysis were conducted following PRISMA guidelines. Electronic databases were searched for in vitro studies evaluating the effects of antioxidants on bond strength to sodium hypochlorite-treated dentin. Two independent reviewers screened articles, extracted data, and assessed risk of bias. Meta-analyses were performed using a random-effects model to compare standardized mean differences in bond strength between antioxidant pretreatment and control groups. Inclusion criteria consisted of in vitro studies that examined the bond strength of resin-based materials to NaOCl-treated dentin with antioxidant application, while exclusion criteria included studies with incomplete data, those not using a control group, or those that did not directly measure bond strength. From 3041 initial records, 29 studies were included in the qualitative analysis and 25 in the meta-analysis. Ascorbic acid, sodium ascorbate, grape seed extract, green tea, and rosmarinic acid significantly improved bond strength to sodium hypochlorite-treated dentin ( p < 0.05). The effectiveness of grape seed extract varied with adhesive system type. Hesperidin, p-toluene sulfonic acid, and sodium thiosulfate did not significantly improve bond strength. Most studies had a high risk of bias. This suggests that the conclusions drawn from these studies should be interpreted with caution, and further research with more robust methodologies may be needed to confirm the findings. In conclusion, this systematic review implies that certain antioxidants can improve bond strength to sodium hypochlorite-treated dentin, with efficacy depending on the specific agent and adhesive system used. Further standardized studies are needed to optimize protocols and confirm these findings. |
