Aerobic exercise and cognitive function in chronic severe traumatic brain injury survivors: a within-subject A-B-A intervention study.

Autor: López LP; Department of Psychobiology and Methodology of Health Sciences, Institute of Neurosciences, Universitat Autònoma de Barcelona. Bellaterra (Cerdanyola del Vallès), Barcelona, Spain., Coll-Andreu M; Department of Psychobiology and Methodology of Health Sciences, Institute of Neurosciences, Universitat Autònoma de Barcelona. Bellaterra (Cerdanyola del Vallès), Barcelona, Spain., Torras-Garcia M; Department of Psychobiology and Methodology of Health Sciences, Institute of Neurosciences, Universitat Autònoma de Barcelona. Bellaterra (Cerdanyola del Vallès), Barcelona, Spain., Font-Farré M; Department of Physical Activity and Sport Sciences, Faculty of Psychology, Education and Sport Sciences (FPCEE), University Ramon Llull, Císter 34, Barcelona, 08022, Spain., Oviedo GR; Department of Physical Activity and Sport Sciences, Faculty of Psychology, Education and Sport Sciences (FPCEE), University Ramon Llull, Císter 34, Barcelona, 08022, Spain.; Department of Kinesiology, Mississippi State University, Mississippi State, USA., Capdevila L; Sport Research Institute, Autonomous University of Barcelona, Bellaterra (Cerdanyola del Vallès), Barcelona, Spain., Guerra-Balic M; Department of Physical Activity and Sport Sciences, Faculty of Psychology, Education and Sport Sciences (FPCEE), University Ramon Llull, Císter 34, Barcelona, 08022, Spain., Portell-Cortés I; Department of Psychobiology and Methodology of Health Sciences, Institute of Neurosciences, Universitat Autònoma de Barcelona. Bellaterra (Cerdanyola del Vallès), Barcelona, Spain., Costa-Miserachs D; Department of Psychobiology and Methodology of Health Sciences, Institute of Neurosciences, Universitat Autònoma de Barcelona. Bellaterra (Cerdanyola del Vallès), Barcelona, Spain., Morris TP; Department of Physical Therapy, Movement and Rehabilitation Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA. tim.peter.morris@gmail.com.; Center for Cognitive and Brain Health, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA. tim.peter.morris@gmail.com.
Jazyk: angličtina
Zdroj: BMC sports science, medicine & rehabilitation [BMC Sports Sci Med Rehabil] 2024 Sep 27; Vol. 16 (1), pp. 201. Date of Electronic Publication: 2024 Sep 27.
DOI: 10.1186/s13102-024-00993-4
Abstrakt: Background: Following acute and sub-acute rehabilitation from severe traumatic brain injury (TBI), minimal to no efficacious interventions to treat ongoing cognitive deficits are available. Aerobic exercise is a non-invasive behavioral intervention with promise to treat cognitive deficits in TBI populations.
Methods: Six individuals, aged 24-62 years, with chronic (> 8 months since injury) severe (Glasgow Coma Scale of 3-8) TBI were recruited from two outpatient rehabilitation centers. In an A-B-A study design, 20-weeks of supervised aerobic exercise interventions were delivered three times per week (phase B) in addition to participants typical rehabilitation schedules (phases A). The effect of phase B was tested on a trail making test part B (primary outcome measure of executive function) as well as objective daily physical activity (PA), using both group level (linear mixed effect models) and single subject statistics.
Results: Five of six participants increased trail-making test part B by more than 10% pre-to-post phase B, with three of six making a clinically meaningful improvement (+ 1SD in normative scores). A significant main effect of time was seen with significant improvement in trail-making test part B pre-to-post exercise (phase B). No significant effects in other planned comparisons were found. Statistically significant increases in daily moderate-to-vigorous PA were also seen during phase B compared to phase A with three of six individuals making a significant behaviour change.
Conclusions: The addition of supervised aerobic exercise to typical rehabilitation strategies in chronic survivors of severe TBI can improve executive set shifting abilities and increase voluntary daily PA levels.
Trial Registration: Retrospective trial registration on July 11 2024 with trial number: ISRCTN17487462.
(© 2024. The Author(s).)
Databáze: MEDLINE
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