Oral administration of cysteine peptides attenuates UV-B-induced skin erythema and pigmentation in humans.

Autor: Sakuma A; Research and Development Division, Mitsubishi Corporation Life Sciences Limited, Tokyo, 100-0006, Japan., Kai Y; Maruishilabo Corporation, Osaka, 531-0071, Japan., Yamasaki Y; Osaka Nishiumeda Clinic, Osaka, 530-0001, Japan., Tanaka T; HUMA R&D CORP, Tokyo, 108-0023, Japan., Sakurai T; Research and Development Division, Mitsubishi Corporation Life Sciences Limited, Tokyo, 100-0006, Japan. takanobu.sakurai@mcls-ltd.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Sep 27; Vol. 14 (1), pp. 22163. Date of Electronic Publication: 2024 Sep 27.
DOI: 10.1038/s41598-024-73447-z
Abstrakt: The oral administration of antioxidants may suppress UV-B-induced skin damage. HITHION YH-15, the extract of Torula yeast (Cyberlindnera jadinii), is rich in cysteine-containing peptides such as reduced and oxidized glutathione (GSH and GSSG), γ-glutamylcysteine (γ-Glu-Cys), and cysteinylglycine (Cys-Gly). These four constituents are termed cysteine peptides. In this study, we investigated the protective effects of cysteine peptides against UV-B in a randomized, placebo-controlled, double-blind, parallel-group study. A total of 90 healthy males and females aged 30-59 years were enrolled and randomized into two groups of 45 individuals each (cysteine peptides (48 mg/day) and placebo). Changes in UV-B-induced erythema and pigmentation were compared between groups after 5 weeks of test food intake. The minimal erythema dose (MED) significantly increased (*p = 0.019) in the cysteine peptides group compared to that in the placebo group, indicating suppression of UV-B-induced erythema. ΔL* value significantly increased (***p < 0.0001) in the cysteine peptides group compared to that in the placebo, indicating pigmentation suppression. We demonstrated that oral administration of cysteine peptides suppresses UV-B-induced erythema and pigmentation through multiple mechanisms. Thus, cysteine peptides may find use as nutricosmetics for maintaining skin health and well-being.UMIN Clinical Trials Registry ID: UMIN 000050157.
(© 2024. The Author(s).)
Databáze: MEDLINE
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