Post-COVID-19 condition in children: epidemiological evidence stratified by acute disease severity.

Autor: Lap CR; Department of Pediatrics - Van Houten research group, Spaarne Gasthuis, Hoofddorp and Haarlem, Haarlem, The Netherlands. c.r.lap@amsterdamumc.nl.; Department of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands. c.r.lap@amsterdamumc.nl.; Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital and University Medical Centre Utrecht, Utrecht, The Netherlands. c.r.lap@amsterdamumc.nl., Brackel CLH; Department of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.; Department of Pediatrics, Tergooi Medical Centrum, Hilversum, The Netherlands., Winkel AMAM; Department of Pediatrics - Van Houten research group, Spaarne Gasthuis, Hoofddorp and Haarlem, Haarlem, The Netherlands.; Department of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands., Hashimoto S; Department of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.; Department of Pulmonary Medicine, Amsterdam UMC University of Amsterdam, Amsterdam, The Netherlands., Haverkort M; Department of Infection Prevention and Control, Public Health Service (GGD) Kennemerland, Haarlem, The Netherlands., Noij LCE; Department of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands., Alsem MW; Department of Rehabilitation Medicine, Amsterdam Movement Sciences, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands., von Asmuth EGJ; Willem Alexander Children's Hospital, Leiden University Medical Centre, Leiden, The Netherlands., Bannier MAGE; Division of Pediatric Respiratory Medicine, Department of Pediatrics, MosaKids Children's Hospital, Maastricht University Medical Centre, Maastricht, The Netherlands., Buddingh EP; Willem Alexander Children's Hospital, Leiden University Medical Centre, Leiden, The Netherlands., van Goudoever JB; Department of Pediatrics, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands., Haverman L; Child and Adolescent Psychiatry & Psychosocial Care, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.; Amsterdam Public Health, Mental Health and Digital Health, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development, Child Development, Amsterdam, The Netherlands., Maitland-van der Zee AH; Department of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.; Department of Pulmonary Medicine, Amsterdam UMC University of Amsterdam, Amsterdam, The Netherlands., Mooij MG; Department of Pediatric Nephrology, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands., Oostrom K; Child and Adolescent Psychiatry & Psychosocial Care, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands., Pijnenburg MW; Division of Pediatric Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus MC -Sophia Children's Hospital, Rotterdam, The Netherlands., Kloosterman S; Division of Pediatric Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus MC -Sophia Children's Hospital, Rotterdam, The Netherlands., Teela L; Child and Adolescent Psychiatry & Psychosocial Care, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.; Amsterdam Public Health, Mental Health and Digital Health, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development, Child Development, Amsterdam, The Netherlands., Luijten M; Child and Adolescent Psychiatry & Psychosocial Care, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.; Amsterdam Public Health, Mental Health and Digital Health, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development, Child Development, Amsterdam, The Netherlands., Tulling AJ; Willem Alexander Children's Hospital, Leiden University Medical Centre, Leiden, The Netherlands., Lugthart G; Willem Alexander Children's Hospital, Leiden University Medical Centre, Leiden, The Netherlands., Bogaert D; Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital and University Medical Centre Utrecht, Utrecht, The Netherlands.; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Biesbroek G; Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands., van Houten MA; Department of Pediatrics - Van Houten research group, Spaarne Gasthuis, Hoofddorp and Haarlem, Haarlem, The Netherlands., Terheggen-Lagro SWJ; Department of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Pediatric research [Pediatr Res] 2024 Sep 27. Date of Electronic Publication: 2024 Sep 27.
DOI: 10.1038/s41390-024-03597-3
Abstrakt: Background: To determine the prevalence of pediatric Post-COVID-19 condition (PPCC), identify risk factors, and assess the quality of life in children with differing severities of acute COVID-19.
Methods: During a prospective longitudinal study with a 1-year follow-up, we compared non-hospitalized (mild) and hospitalized (severe) COVID-19 cases to a negatively tested control group.
Results: 579 children were included in this study. Of these, 260 had mild acute disease (median age:8, IQR:6-10), 60 had severe acute disease (median age:1, IQR:0.1-4.0), and 259 tested negative for SARS-CoV-2 (NT) (median age:8, IQR:5-10). At three months, 14.6% of the SARS-CoV-2 positive mild group (RR:6.31 (CI 95%: 2.71-14.67)) and 29.2% of the severe group (RR:12.95 (CI 95%: 5.37-31.23)) reported sequelae, versus 2.3% of the NT group. PPCC prevalence in the mild group decreased from 16.1% at one month to 4.4% at one year. Children with PPCC exhibited lower physical health-related quality of life scores and higher fatigue scores than the NT children.
Conclusions: Severe acute COVID-19 in children leads to a higher PPCC prevalence than in mild cases. PPCC prevalence decreases over time. Risk factors at three months include prior medical history, hospital admission, and persistent fatigue one month after a positive test.
Impact: We demonstrate children with severe COVID-19 are more likely to develop Post-COVID-19 condition than those with mild or no infections, and highlights the risk factors. Here we have stratified by acute disease severity, prospectively included a negative control group, and have demonstrated the heterogeneity in prevalence when utilizing various recent definitions of post-COVID. Identifying risk factors for pediatric post-COVID and highlighting the heterogeneity in prevalence based on various current definitions for post-COVID should aid in correctly identifying potential pediatric post-COVID cases, aiding in early intervention.
(© 2024. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)
Databáze: MEDLINE
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