Spatio-temporal distribution of rhinovirus types in Kenya: a retrospective analysis, 2014.

Autor: Morobe JM; Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya. jmwita@kemri-wellcome.org., Kamau E; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Luka MM; Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya., Murunga N; Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya., Lewa C; Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya., Mutunga M; Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya., Bigogo G; KEMRI- Centre for Global Health Research, Kisumu, Kenya., Otieno N; KEMRI- Centre for Global Health Research, Kisumu, Kenya., Nyawanda B; KEMRI- Centre for Global Health Research, Kisumu, Kenya., Onyango C; Division of Global Health Protection, U.S Centers for Disease Control and Prevention (CDC), Centers for Global Health, Nairobi, Kenya., Nokes DJ; Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya.; School of Life Sciences, Zeeman Institute for Systems Biology and Infectious Disease Epidemiology Research (SBIDER), University of Warwick, Coventry, UK., Agoti CN; Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya.; Department of Public Health, Pwani University, Kilifi, Kenya., Munywoki PK; Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, Kenya.; Division of Global Health Protection, U.S Centers for Disease Control and Prevention (CDC), Centers for Global Health, Nairobi, Kenya.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Sep 27; Vol. 14 (1), pp. 22298. Date of Electronic Publication: 2024 Sep 27.
DOI: 10.1038/s41598-024-73856-0
Abstrakt: The epidemiology and circulation patterns of various rhinovirus types within populations remains under-explored. We generated 803 VP4/VP2 gene sequences from rhinovirus-positive samples collected from acute respiratory illness (ARI) patients, including both in-patient and outpatient cases, between 1st January and 31st December 2014 from eleven surveillance sites across Kenya and used phylogenetics to characterise virus introductions and spread. RVs were detected throughout the year, with the highest detection rates observed from January to March and June to July. We detected a total of 114 of the 169 currently classified types. Our analysis revealed numerous virus introductions into Kenya characterized by local expansion and extinction, and extensive spatial mixing of types within the country due to the widespread transmission of the virus after an introduction. This work demonstrates that in a single year, the circulation of rhinovirus in Kenya was characterized by substantial genetic diversity, multiple introductions, and extensive geographical spread.
(© 2024. The Author(s).)
Databáze: MEDLINE
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