A hierarchical atlas of the human cerebellum for functional precision mapping.

Autor: Nettekoven C; Western Institute for Neuroscience, Western University, London, ON, Canada. cr.nettekoven@gmail.com.; Department of Computer Science, Western University, London, ON, Canada. cr.nettekoven@gmail.com., Zhi D; Western Institute for Neuroscience, Western University, London, ON, Canada.; Department of Computer Science, Western University, London, ON, Canada., Shahshahani L; Western Institute for Neuroscience, Western University, London, ON, Canada., Pinho AL; Western Institute for Neuroscience, Western University, London, ON, Canada.; Department of Computer Science, Western University, London, ON, Canada., Saadon-Grosman N; Harvard University, Cambridge, USA., Buckner RL; Harvard University, Cambridge, USA., Diedrichsen J; Western Institute for Neuroscience, Western University, London, ON, Canada. jdiedric@uwo.ca.; Department of Computer Science, Western University, London, ON, Canada. jdiedric@uwo.ca.; Department of Statistical and Actuarial Sciences, Western University, London, ON, Canada. jdiedric@uwo.ca.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Sep 27; Vol. 15 (1), pp. 8376. Date of Electronic Publication: 2024 Sep 27.
DOI: 10.1038/s41467-024-52371-w
Abstrakt: The human cerebellum is activated by a wide variety of cognitive and motor tasks. Previous functional atlases have relied on single task-based or resting-state fMRI datasets. Here, we present a functional atlas that integrates information from seven large-scale datasets, outperforming existing group atlases. The atlas has three further advantages. First, the atlas allows for precision mapping in individuals: the integration of the probabilistic group atlas with an individual localizer scan results in a marked improvement in prediction of individual boundaries. Second, we provide both asymmetric and symmetric versions of the atlas. The symmetric version, which is obtained by constraining the boundaries to be the same across hemispheres, is especially useful in studying functional lateralization. Finally, the regions are hierarchically organized across three levels, allowing analyses at the appropriate level of granularity. Overall, the present atlas is an important resource for the study of the interdigitated functional organization of the human cerebellum in health and disease.
(© 2024. The Author(s).)
Databáze: MEDLINE
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