Impaction-based exhaled breath sampling for substance monitoring: a prospective pilot study (Drugxhale).

Autor:	de Jong LAA; Department of Clinical Pharmacy, Expert Centre Gelre-iLab, Gelre Hospitals, PO Box 9014, 7300 DS Apeldoorn, The Netherlands., Olyslager EJH; Department of Clinical Pharmacy, Expert Centre Gelre-iLab, Gelre Hospitals, PO Box 9014, 7300 DS Apeldoorn, The Netherlands., Wieferink JA; Department of Clinical Pharmacy, Expert Centre Gelre-iLab, Gelre Hospitals, PO Box 9014, 7300 DS Apeldoorn, The Netherlands., Keizer M; Tactus Addiction Treatment centre, PO Box 154, 7400 AD Deventer, The Netherlands., Cornielje T; Tactus Addiction Treatment centre, PO Box 154, 7400 AD Deventer, The Netherlands., Zuidema RP; Department of Clinical Pharmacy, Expert Centre Gelre-iLab, Gelre Hospitals, PO Box 9014, 7300 DS Apeldoorn, The Netherlands.
Jazyk:	angličtina
Zdroj:	Journal of breath research [J Breath Res] 2024 Oct 14; Vol. 19 (1). Date of Electronic Publication: 2024 Oct 14.
DOI:	10.1088/1752-7163/ad80b6
Abstrakt:	For decades, intake monitoring of drugs using urine as the matrix of choice is the gold standard in drug treatment centers. A properly conducted urine drug test can identify recent use of prescribed, non-prescribed and illicit drugs. However, issues like adulteration, substitution and privacy issues have driven the search for alternative matrices. This prospective pilot study evaluates the use of an impaction-based breath sampling device, Breath Explor ® , as an alternative to traditional urine-based drug monitoring. Breath samples were analyzed using a validated 32-component liquid chromatography-tandem mass spectrometry method. Recovery data represent the efficiency of extracting the analytes from the breath devices. Both automated and manual processing of the Breath Explor® devices showed mean recovery rates ranging from 39.5% to 55.4% for the 32 analytes. Despite the small number of subjects, breath analysis proved to be a convenient and easy-to-use methodology. An overall kappa-values of 0.5 indicated a moderate level of agreement with urine analysis, underscoring its potential as a complementary diagnostic tool. All participants tested positive in their breath sample for methadone (70% methadone and 100% EDDP), while a significant portion (90%) tested positive for 6-monoacetylmorphine. This innovative approach offers several advantages, including non-invasiveness, reduced risk of adulteration, and the ability to perfom repeated automated sampling and confirmation testing. These findings suggest that breath-based substance monitoring could complement or even replace traditional urine-based methods in clinical practice. (© 2024 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu