Single nucleotide polymorphisms of CFAP43 and TEX14 associated with idiopathic male infertility in a Vietnamese population.

Autor:	Dinh TH; Institute of Genome Research, Vietnam Academy of Science and Technology, Hanoi, Vietnam., Phuong Anh N; Institute of Genome Research, Vietnam Academy of Science and Technology, Hanoi, Vietnam., Thao DH; Institute of Genome Research, Vietnam Academy of Science and Technology, Hanoi, Vietnam., Duy D; Institute of Genome Research, Vietnam Academy of Science and Technology, Hanoi, Vietnam., Bac ND; Department of Human Anatomy, Vietnam Military Medical University, Hanoi, Vietnam., Quyet PV; Institute of Genome Research, Vietnam Academy of Science and Technology, Hanoi, Vietnam.; Military Institute of Clinical Embryology and Histology, Vietnam Military Medical University, Hanoi, Vietnam., Son TT; Military Institute of Clinical Embryology and Histology, Vietnam Military Medical University, Hanoi, Vietnam., Lan Anh LT; Department of Medical Biology and Genetics, Hanoi Medical University, Ministry of Health, Hanoi, Vietnam., Canh NX; Department of Microbial Biotechnology, Faculty of Biotechnology, Vietnam National University of Agriculture, Hanoi, Vietnam., Hai NV; Institute of Genome Research, Vietnam Academy of Science and Technology, Hanoi, Vietnam., Duong NT; Institute of Genome Research, Vietnam Academy of Science and Technology, Hanoi, Vietnam.
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2024 Sep 27; Vol. 103 (39), pp. e39839.
DOI:	10.1097/MD.0000000000039839
Abstrakt:	Male infertility is a multifactorial disease due to spermatogenesis impairment, with etiology remaining unknown for roughly one-third of infertile cases. Several studies have demonstrated that genetic variants are male infertility risk factors. CFAP43 and TEX14 are involved in the spermatogenesis process. The present study aimed to assess the association between single-nucleotide polymorphisms (SNPs) in CFAP43 (rs17116635 and rs10883979) and TEX14 (rs79813370 and rs34818467) and idiopathic male infertility in a Vietnamese population. A cohort of 206 infertile men and 195 controls were recruited for the study. CFAP43 and TEX14 SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genotypes of randomly selected samples, accounting for 10% of the total, were confirmed using Sanger sequencing. The obtained data were analyzed using statistical methods. The results showed that 4 SNPs (rs17116635, rs10883979, rs79813370, and rs34818467) were in accordance with Hardy-Weinberg Equilibrium (HWE; P > .05). CFAP43 rs10883979 and TEX14 rs79813370 were associated with male infertility. For CFAP43 rs10883979, in the recessive model, the combination AA + AG was associated with male infertility when compared to the GG genotype (OR = 0.26; 95% CI: 0.06-0.85; P = .02). For TEX14 rs79813370, a protective effect against infertility risk was identified in the presence of the T allele of rs79813370 when compared to the G allele (OR = 0.48; 95% CI: 0.32-0.72; P < .001). Our results suggest that CFAP43 rs10883979 and TEX14 rs79813370 are likely associated with male infertility in the Vietnamese population, in which the G allele of rs79813370 may be a risk factor for male infertility. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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