| Autor: |
Perini JA; Research Laboratory of Pharmaceutical Sciences (LAPESF), Rio de Janeiro State University (West Zone-UERJ-ZO), Rio de Janeiro 23070-200, RJ, Brazil.; Post-Graduation Program in Environmental Science and Technology, Rio de Janeiro State University (West Zone-UERJ-ZO), Rio de Janeiro 23070-200, RJ, Brazil., Silva YMHD; Research Laboratory of Pharmaceutical Sciences (LAPESF), Rio de Janeiro State University (West Zone-UERJ-ZO), Rio de Janeiro 23070-200, RJ, Brazil.; Post-Graduation Program in Environmental Science and Technology, Rio de Janeiro State University (West Zone-UERJ-ZO), Rio de Janeiro 23070-200, RJ, Brazil., Silva MCD; Research Laboratory of Pharmaceutical Sciences (LAPESF), Rio de Janeiro State University (West Zone-UERJ-ZO), Rio de Janeiro 23070-200, RJ, Brazil., Silva BP; Research Laboratory of Pharmaceutical Sciences (LAPESF), Rio de Janeiro State University (West Zone-UERJ-ZO), Rio de Janeiro 23070-200, RJ, Brazil., Machado DE; Research Laboratory of Pharmaceutical Sciences (LAPESF), Rio de Janeiro State University (West Zone-UERJ-ZO), Rio de Janeiro 23070-200, RJ, Brazil., Moreira MFR; Center for Studies on Worker Health and Human Ecology (CESTEH), National School of Public Health (ENSP), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21041-210, RJ, Brazil. |
| Abstrakt: |
Cadmium (Cd) is a toxic metal which is harmful to humans and the environment. Cd levels and adverse effects may be associated with genetic polymorphisms in genes involved in its toxicokinetics. This study investigated Cd levels in 198 residents of a condominium in Rio de Janeiro, Brazil, built on industrial steel slag waste and the influence of glutathione S-transferase pi isoform 1 ( GSTP1 ) rs1695 A>G polymorphism. Polymorphism was genotyped using a validated TaqMan assay; Cd levels were measured in blood (BCd) and urine (UCd) by graphite furnace atomic absorption spectrometry. Associations were evaluated by multiple logistic regression, odds ratios (ORs), and 95% confidence intervals (CIs). The mean Cd levels were 0.70 ± 0.20 µg L -1 (BCd), 0.58 ± 0.57 µg L -1 (UCd), and 0.61 ± 0.65 µg g -1 in urine corrected by creatinine (UcCd), and the Cd results were above tolerable levels (BCd > 0.5 µg L -1 ) in 87.4% of subjects. Higher blood Cd levels (>0.69 µg L -1 ) were associated with respiratory disease (OR = 2.4; 95%CI = 1.2-5.0), as almost 30% of people with respiratory diseases had higher Cd levels. The GSTP1 rs1695AA genotype frequency was 38.1%, and there were no significant differences between the SNP and Cd levels. High Cd levels and a high prevalence of diseases highlight the importance of implementing public policies and the continuous monitoring of this at-risk population. |
