Sulfated Bile Acids in Serum as Potential Biomarkers of Disease Severity and Mortality in COVID-19.

Autor: Porru E; Occupational Medicine Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, 40138 Bologna, Italy., Comito R; Division of Occupational Medicine, 'IRCCS' Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy., Interino N; Laboratorio di Proteomica Metabolomica e Chimica Bioanalitica, 'IRCCS' Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy., Cerrato A; Department of Chemistry, 'Sapienza' University of Rome, 00185 Rome, Italy., Contoli M; Respiratory Section, Department of Morphology, Surgery, and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy., Rizzo P; Laboratory for Technologies of Advanced Therapies 'LTTA', Department of Translaqutional Medicine, University of Ferrara, 44121 Ferrara, Italy.; Maria Cecilia Hospital, GVM Care & Research, 48022 Cotignola, Italy., Conti M; Local Unit of Imola, Department of Public Health, Health Service of the Emilia-Romagna Region, 40026 Imola, Italy., Campo G; Cardiovascular Institute, Azienda Ospedaliero, University of Ferrara, 44124 Ferrara, Italy., Spadaro S; Intensive Care Unit, Department of Morphology, Surgery, and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy., Caliceti C; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40123 Bologna, Italy.; Biostructures and Biosystems National Institute 'INBB', 00136 Rome, Italy.; Interdepartmental Centre for Industrial Agrofood Research-CIRI Agrofood, University of Bologna, 47521 Cesena, Italy.; Interdepartmental Center of Industrial Research 'CIRI'-Energy and Environment, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy., Marini F; Department of Chemistry, 'Sapienza' University of Rome, 00185 Rome, Italy., Capriotti AL; Department of Chemistry, 'Sapienza' University of Rome, 00185 Rome, Italy., Laganà A; Department of Chemistry, 'Sapienza' University of Rome, 00185 Rome, Italy., Roda A; Biostructures and Biosystems National Institute 'INBB', 00136 Rome, Italy.; Department of Chemistry 'G. Ciamician', Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.
Jazyk: angličtina
Zdroj: Cells [Cells] 2024 Sep 19; Vol. 13 (18). Date of Electronic Publication: 2024 Sep 19.
DOI: 10.3390/cells13181576
Abstrakt: The fight against coronavirus disease 2019 (COVID-19) continues. Since the pandemic's onset, several biomarkers have been proposed to assess the diagnosis and prognosis of this disease. This research aimed to identify potential disease severity biomarkers in serum samples of patients with COVID-19 during the disease course. Data were collected using untargeted and targeted mass spectrometry methods. The results were interpreted by performing univariate and multivariate analyses. Important metabolite classes were identified by qualitative untargeted metabolomics in 15 serum samples from survivors of COVID-19. Quantitative targeted metabolomics on a larger patient cohort including 15 non-survivors confirmed serum 3-sulfate bile acids (i.e. GLCA-3S) were significantly increased in non-survivors compared to survivors during the early disease stage ( p -value < 0.0001). Notably, it was associated with a higher risk of mortality (odds ratio of 26). A principal component analysis showed the ability to discriminate between survivors and non-survivors using the BA concentrations. Furthermore, increased BA-S is highly correlated with known parameters altered in severe clinical conditions.
Databáze: MEDLINE
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