Glandular cell products in adult cestode: A new tale of tapeworm interaction with fish innate immune response.

Autor:	Dezfuli BS; Department of Life Sciences & Biotechnology, University of Ferrara, St. Borsari 46, 44121, Ferrara, Italy., Lorenzoni M; Department of Chemistry, Biology and Biotechnology, University of Perugia, St. Elce di Sotto 5, 06123, Perugia, Italy., Carosi A; Department of Chemistry, Biology and Biotechnology, University of Perugia, St. Elce di Sotto 5, 06123, Perugia, Italy., Bosi G; Department of Veterinary Medicine and Animal Sciences, University of Milan, St. University 6, 26900, Milan, Italy., Franchella E; Department of Life Sciences & Biotechnology, University of Ferrara, St. Borsari 46, 44121, Ferrara, Italy., Poddubnaya LG; Papanin Institute for Biology of Inland Waters, Russian Academy of Sciences, 152742, Borok, Yaroslavl District, Russia.
Jazyk:	angličtina
Zdroj:	International journal for parasitology. Parasites and wildlife [Int J Parasitol Parasites Wildl] 2024 Sep 14; Vol. 25, pp. 100991. Date of Electronic Publication: 2024 Sep 14 (Print Publication: 2024).
DOI:	10.1016/j.ijppaw.2024.100991
Abstrakt:	The caryophyllidean tapeworm Caryophyllaeus brachycollis (Janiszewska, 1953) is indigenous to the Lake Blidinje in the west-central part of Bosnia-Herzegovina where it infects chub Squalius tenellus (Heckel, 1843). Of 22 chubs examined, 45% were infected with C. brachycollis and a total of 912 specimens of this worm were counted. Histopathological and ultrastructural investigations were conducted on interface region between chub intestine and cestode scolex. Different sizes of lipid droplets in cestode tegument, in interface region and in chub enterocytes were observed. C. brachycollis lacks any specialized attachment organs and with an expanded, flattened scolex goes deep in mucosal folds and firmly attaches to them. In the epithelium of fish intestine, near the site of worm attachment, a high number of mucous cells and several rodlet cells were noticed. Indeed, within the intestinal tunica propria-submucosa, beneath the site of scolex attachment, numerous neutrophils and mast cells were encountered. Transmission electron microscopy of the apical part of the scolex of C. brachycollis showed the occurrence of a multicellular, syncytial glandular complex, the scolex produced membrane-bound secretory granules and their fibrillar contents discharged by merocrine and apocrine secretion onto the host-parasite interface. Our results are among the first to provide evidence on the sophisticated relationship between fish intestine and amorphous-undefinable substance produced by scolex glandular complex. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2024 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.)
Databáze:	MEDLINE
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