Endometrial Adenocarcinoma After a Benign Biopsy Without Atypia: A Case Report.
| Autor: | DeMartino S; Obstetrics and Gynecology, West Virginia School of Osteopathic Medicine, Huntington, USA., Keefer JM; Surgery, Joan C. Edwards School of Medicine, Marshall University, Huntington, USA., Huff C; Obstetrics and Gynecology, Valley Health, Huntington, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Aug 27; Vol. 16 (8), pp. e67906. Date of Electronic Publication: 2024 Aug 27 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.67906 |
| Abstrakt: | Endometrial biopsy is a highly effective screening procedure used to determine endometrial cancer and its precursors. This is often used to rule out endometrial cancer, the most common gynecologic cancer in the United States, before a total hysterectomy. This is a case of a benign endometrial biopsy that was ultimately malignant in the post-operative pathology report. A 37-year-old female presents with a six-month history of dysmenorrhea, passage of large clots, and pelvic pain, seeking definitive treatment with a hysterectomy. The pre-operative assessment included ultrasound, hysteroscopic exam, and endometrial biopsy. The ultrasound demonstrated evidence of adenomyosis due to the heterogeneous appearance of the myometrium and an endometrial stripe of 36 mm. Endometrial biopsy using pipelle was performed alongside an in-office hysteroscopic exam, which had a hyperplastic appearance of the endometrium. The biopsy resulted in hyperplasia without atypia and scant polypoid endometrial tissue. The patient underwent a total laparoscopic hysterectomy and bilateral salpingectomy without complications. The post-operative pathology report indicated a grade 2 invasive endometrial adenocarcinoma extending through 75% of the myometrium. Incidental diagnosis of endometrial adenocarcinoma following total hysterectomy is rare and poses significant medical implications. Endometrial hyperplasia without atypia has a low risk of progressing to endometrial carcinoma over time. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, DeMartino et al.) |
| Databáze: | MEDLINE |
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