Dermatologic Conditions in Down Syndrome: A Multi-Site Retrospective Review of International Classification of Diseases Codes.

Autor: Rakasiwi T; Department of Dermatology, Dartmouth Health, Manchester, New Hampshire, USA., Ryan C; Geisel Medical School, Hanover, New Hampshire, USA., Stein A; Pediatric Dermatology Research Alliance, Portland, Oregon, USA., Vu A; Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Dykman M; University of Minnesota Medical School, Minneapolis, Minnesota, USA., Shah I; Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Reilly C; Georgetown University School of Medicine, Washington, DC, USA., Brokamp G; Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Mologousis MA; Tufts University School of Medicine, Boston, Massachusetts, USA., Komishke B; Division of Dermatology, The Hospital for Sick Children, Toronto, Ontario, Canada., Hou V; University of Colorado Medical School, Aurora, Colorado, USA., Maguiness S; Department of Dermatology, M Health Fairview, Minneapolis, Minnesota, USA., Kirkorian AY; Division of Dermatology, Children's National Hospital, Washington, DC, USA.; George Washington University School of Medicine and Health Sciences, Washington, DC, USA., Price H; Division of Dermatology, Phoenix Children's Hospital, Phoenix, Arizona, USA., Hawryluk EB; Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA., Fernandez Faith E; Division of Dermatology, Nationwide Children's Hospital, Columbus, Ohio, USA., Lara-Corrales I; Division of Dermatology, The Hospital for Sick Children, Toronto, Ontario, Canada., Gurnee E; Department of Dermatology, University of Colorado, Aurora, Colorado, USA., Holland KE; Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Rork JF; Department of Dermatology, Dartmouth Health, Manchester, New Hampshire, USA.; Department of Pediatrics, Dartmouth Health, Manchester, New Hampshire, USA.
Jazyk: angličtina
Zdroj: Pediatric dermatology [Pediatr Dermatol] 2024 Sep 26. Date of Electronic Publication: 2024 Sep 26.
DOI: 10.1111/pde.15757
Abstrakt: Background and Objective: As the population and life expectancy of people with Down syndrome increases, identifying common skin conditions throughout the lifespan will help inform clinical care and research. We sought to evaluate dermatologic conditions diagnosed in pediatric and adult patients with Down syndrome.
Methods: This multicenter retrospective study analyzed demographic and outpatient visit International Classification of Diseases codes of patients with Down syndrome evaluated at outpatient dermatology clinics in the United States or Canada between 2011 and 2021.
Results: A total of 1529 patients with Down syndrome were identified from eight academic medical centers: 50.8% were children (0-12 years), 25.2% were adolescents (13-17 years), and 24% were adults (18 years and older). Eczematous dermatitis was the most common diagnosis overall (26%), followed by folliculitis (19.3%) and seborrheic dermatitis (15.6%). Other notable diagnoses included dermatophyte infections (13%), alopecia areata (11.6%), and psoriasis (6.7%). About 4.3% of visits included a code for high-risk medication use. Eczematous dermatitis, alopecia areata, and folliculitis were the most common diagnoses observed in children; folliculitis, hidradenitis suppurativa, and eczematous dermatitis in adolescents; and seborrheic dermatitis, eczematous dermatitis, and folliculitis in adults.
Conclusions: Dermatologic conditions in patients with Down syndrome vary by age, but are most often eczematous, adnexal, and cutaneous autoimmune disorders. This multicenter retrospective review identifies skin diseases that should be prioritized for clinical care guideline development and research in the Down syndrome community.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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