TDP-43 nuclear condensation and neurodegenerative proteinopathies.

Autor: Vassallu F; IFIBIO Houssay, Grupo de Neurociencia de Sistemas, Facultad de Medicina, Universidad de Buenos Aires - CONICET, Buenos Aires, Argentina., Igaz LM; IFIBIO Houssay, Grupo de Neurociencia de Sistemas, Facultad de Medicina, Universidad de Buenos Aires - CONICET, Buenos Aires, Argentina. Electronic address: lmuller@fmed.uba.ar.
Jazyk: angličtina
Zdroj: Trends in neurosciences [Trends Neurosci] 2024 Nov; Vol. 47 (11), pp. 849-850. Date of Electronic Publication: 2024 Sep 25.
DOI: 10.1016/j.tins.2024.09.003
Abstrakt: RNA-binding proteins (RBPs) can undergo phase separation and form condensates, processes that, in turn, can be critical for their functionality. In a recent study, Huang, Ellis, and colleagues show that cellular stress can trigger transient alterations in nuclear TAR DNA-binding protein 43 (TDP-43), leading to changes crucial for proper neuronal function. These findings have implications for understanding neurological TDP-43 proteinopathies.
Competing Interests: Declaration of interests The authors declare no competing interests.
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Databáze: MEDLINE
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