First report of Trypanosoma cruzi infection in urban hedgehog (Atelerix albiventris) in Colombia.

Autor: Murcia-Cueto IS; Grupo de Investigación en Ciencias Animales GRICA, Facultad de Medicina Veterinaria y Zootecnia, Universidad Cooperativa de Colombia UCC, Bucaramanga, Colombia., Duarte-Rodríguez LZB; Grupo de Investigación en Ciencias Animales GRICA, Facultad de Medicina Veterinaria y Zootecnia, Universidad Cooperativa de Colombia UCC, Bucaramanga, Colombia., Jiménez-Leaño ÁP; Grupo de Investigación en Ciencias Animales GRICA, Facultad de Medicina Veterinaria y Zootecnia, Universidad Cooperativa de Colombia UCC, Bucaramanga, Colombia., Cantillo-Barraza O; Grupo de Biología y Control de Enfermedades Infecciosas - BCEI, Facultad de Ciencias Exactas y Naturales (FCEN), Universidad de Antioquia (UDEA), Medellín, Colombia., Ospina CM; Centro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá, Colombia., Patiño LH; Centro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá, Colombia., Ramírez JD; Centro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá, Colombia; Molecular Microbiology Laboratory, Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Jaimes-Dueñez J; Grupo de Investigación en Ciencias Animales GRICA, Facultad de Medicina Veterinaria y Zootecnia, Universidad Cooperativa de Colombia UCC, Bucaramanga, Colombia. Electronic address: jeiczon.jaimes@campusucc.edu.co.
Jazyk: angličtina
Zdroj: Veterinary parasitology, regional studies and reports [Vet Parasitol Reg Stud Reports] 2024 Oct; Vol. 55, pp. 101116. Date of Electronic Publication: 2024 Sep 15.
DOI: 10.1016/j.vprsr.2024.101116
Abstrakt: Chagas disease (CD) is a zoonotic infection caused by the protozoan parasite Trypanosoma cruzi, affecting over seven million people worldwide. T. cruzi can infect more than 100 species of wild mammals, including opossums, armadillos, bats, carnivores, rodents, and primates, as well as domestic animals like dogs, cats, and exotic pets. This is the first report of T. cruzi infection in an "exotic pet" African hedgehog (Atelerix albiventris), in an endemic area for CD in Colombia. After the patient underwent euthanasia due to worsening clinical signs including diarrhea, thrombocytopenia, leukopenia, and hemiplegia, anatomopathological and histopathological examinations were conducted. Simultaneously, molecular diagnosis and genotyping of T. cruzi were performed using qPCR and Next Generation sequencing of the 18S rRNA gene, respectively. Anatomopathological examination revealed significant changes across various systems, including ulcerative hemorrhagic enteritis, left ventricular hypertrophy, lymphadenitis and diffuse meningeal edema. The main histopathological findings included mononuclear inflammatory reaction, congestion and hemorrhages in several organs, accompanied of amastigote cysts in cardiomyocytes. qPCR confirmed the presence of T. cruzi in heart, lymph node, brain, salivary gland, blood, and spleen. Regarding genotyping analyses, all organs were positive for TcI. This case confirms the susceptibility of A. albiventris to infection with T. cruzi and suggest a potential role for these pets as disseminators of T. cruzi infection in endemic areas. The ecological and epidemiological implications of these findings are discussed here.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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