Modeling the progression of neuropsychiatric symptoms in Alzheimer's disease with PET-based Braak staging.

Autor: Macedo AC; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue West, Montréal, QC H3A 1A1, Canada; Montreal Neurological Institute, 3801 University Street, Montréal, QC H3A 2B4, Canada., Therriault J; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue West, Montréal, QC H3A 1A1, Canada; Montreal Neurological Institute, 3801 University Street, Montréal, QC H3A 2B4, Canada., Tissot C; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue West, Montréal, QC H3A 1A1, Canada; Montreal Neurological Institute, 3801 University Street, Montréal, QC H3A 2B4, Canada; Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, USA., Aumont É; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Psychology, University of Québec at Montréal, 100 Rue Sherbrooke O, Montréal, QC H2X 3P2, Canada., Servaes S; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue West, Montréal, QC H3A 1A1, Canada; Montreal Neurological Institute, 3801 University Street, Montréal, QC H3A 2B4, Canada., Rahmouni N; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue West, Montréal, QC H3A 1A1, Canada; Montreal Neurological Institute, 3801 University Street, Montréal, QC H3A 2B4, Canada., Fernandez-Arias J; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue West, Montréal, QC H3A 1A1, Canada; Montreal Neurological Institute, 3801 University Street, Montréal, QC H3A 2B4, Canada., Lussier FZ; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Psychiatry, University of Pittsburgh, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA., Wang YT; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue West, Montréal, QC H3A 1A1, Canada; Montreal Neurological Institute, 3801 University Street, Montréal, QC H3A 2B4, Canada., Ng KP; Department of Neurology, National Neuroscience Institute, 11 Jln Tan Tock Seng, Singapore 308433, Singapore., Vermeiren M; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada., Bezgin G; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue West, Montréal, QC H3A 1A1, Canada; Montreal Neurological Institute, 3801 University Street, Montréal, QC H3A 2B4, Canada., Socualaya KQ; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue West, Montréal, QC H3A 1A1, Canada; Montreal Neurological Institute, 3801 University Street, Montréal, QC H3A 2B4, Canada., Stevenson J; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue West, Montréal, QC H3A 1A1, Canada; Montreal Neurological Institute, 3801 University Street, Montréal, QC H3A 2B4, Canada., Hosseini SA; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue West, Montréal, QC H3A 1A1, Canada; Montreal Neurological Institute, 3801 University Street, Montréal, QC H3A 2B4, Canada., Chamoun M; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue West, Montréal, QC H3A 1A1, Canada; Montreal Neurological Institute, 3801 University Street, Montréal, QC H3A 2B4, Canada., Ferrari-Souza JP; Department of Psychiatry, University of Pittsburgh, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA., Ferreira PCL; Department of Psychiatry, University of Pittsburgh, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA., Bellaver B; Department of Psychiatry, University of Pittsburgh, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA., Leffa DT; Department of Psychiatry, University of Pittsburgh, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA., Vitali P; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue West, Montréal, QC H3A 1A1, Canada; Montreal Neurological Institute, 3801 University Street, Montréal, QC H3A 2B4, Canada., Zimmer ER; Department of Pharmacology, Graduate Program in Biological Sciences: Pharmacology and Therapeutics; and Biochemistry, Universidade Federal do Rio Grande do Sul, 2600 Ramiro Barcelo St, Porto Alegre, RS 90.035-003, Brazil; Brain Institute of Rio Grande do Sul, PUCRS, Av. Ipiranga, 6690, Porto Alegre, RS 90610-000, Brazil., Ismail Z; Departments of Psychiatry, Clinical Neurosciences, Community Health Sciences, and Pathology, Hotchkiss Brain Institute and O'Brien Institute of Public Health, University of Calgary, Calgary, AB, Canada; National Institute for Health and Care Research Exeter Biomedical Research Centre, University of Exeter, Exeter, UK., Pascoal TA; Department of Psychiatry, University of Pittsburgh, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA., Gauthier S; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue West, Montréal, QC H3A 1A1, Canada., Rosa-Neto P; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Mental Health Institute, Montréal, 6875 LaSalle Blvd, Montréal, QC H4H 1R3, Canada; Department of Neurology and Neurosurgery, McGill University, 1033 Pine Avenue West, Montréal, QC H3A 1A1, Canada; Montreal Neurological Institute, 3801 University Street, Montréal, QC H3A 2B4, Canada. Electronic address: pedro.rosa@mcgill.ca.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2024 Dec; Vol. 144, pp. 127-137. Date of Electronic Publication: 2024 Sep 20.
DOI: 10.1016/j.neurobiolaging.2024.09.009
Abstrakt: In Alzheimer's disease (AD), neuropsychiatric symptoms (NPS) correlate with tau deposition in the brain. Here, we investigated the association of PET-based Braak stages with NPS and assessed whether they predict annual changes in NPS. We evaluated 231 individuals in the aging and AD continuum. Participants were assigned a Braak stage at baseline and followed for 1.97 (s.d. 0.62) years. NPS were investigated using the Mild Behavioral Impairment Checklist (MBI-C) and the Neuropsychiatric Inventory Questionnaire severity (NPI-Q-S) and distress (NPI-Q-D) scales. Multiple linear regressions (MLR) assessed the association of Braak stages with baseline NPS and the annual change in NPS scores. At baseline, stages I-II, III-IV, and V-VI were associated with higher MBI-C, NPI-Q-S, and NPI-Q-D scores. Stages V-VI were associated with a significant annual increase in MBI-C scores. These findings suggest that tau accumulation may manifest clinically with an increase in NPS, which seems to be an early event in AD pathophysiology. Moreover, PET-based Braak staging appears to be a good predictor of NPS severity progression.
Competing Interests: Declaration of Interest E.R.Z. serves on the scientific advisory board of Next Innovative Therapeutics. Z.I. has served as an advisor/consultant to CADTH, Eisai, Eli Lilly, Lundbeck/Otsuka, Novo Nordisk, and Roche. S.G. has served as a scientific advisor to Cerveau Therapeutics. Outside the work presented in this paper, P.R.N. provides consultancy services for Roche, Cerveau Radiopharmaceuticals, Lilly, Eisai, Pfizer, and Novo Nordisk. P.R.N. also serves as a clinical trials investigator for Biogen and Novo Nordisk. The other authors declare that they have no competing interests.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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