Serum D-asparagine concentration adjusted for eGFR could serve as a novel screening tool for urothelial carcinoma.

Autor: Yamamoto A; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Kawashima A; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan. Electronic address: kawashima@uro.med.osaka-u.ac.jp., Sakai S; Department of Nephrology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Mita M; KAGAMI Inc., Ibaraki, Osaka, 567-0082, Japan., Sassi N; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Inoguchi S; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Horibe Y; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Yoshimura A; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Tani M; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Yutong L; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Okuda Y; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Oka T; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Uemura T; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Yamamichi G; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Ishizuya Y; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Hayashi T; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Yamamoto Y; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Kato T; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Hatano K; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Kakuta Y; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan., Imamura R; Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan., Takahara S; Kansai Medical Clinic for Renal Transplantation, Toyonaka, Osaka, 560-0083, Japan., Kimura T; Department of Nephrology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan; Kansai Medical Clinic for Renal Transplantation, Toyonaka, Osaka, 560-0083, Japan., Nonomura N; Department of Urology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
Jazyk: angličtina
Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Nov 12; Vol. 733, pp. 150701. Date of Electronic Publication: 2024 Sep 14.
DOI: 10.1016/j.bbrc.2024.150701
Abstrakt: The sensitivity of currently available screening tools for urothelial carcinoma (UC) remains unsatisfactory particularly at early stages. Hence, we aimed to establish a novel blood-based screening tool for urothelial carcinoma. We measured serum d-amino acid levels in 108 and 192 patients with and without UC individuals in the derivation cohort, and 15 and 25 patients with and without UC in the validation cohort. Serum d-asparagine levels were significantly higher in patients with UC than in those without UC (p < 0.0001). We developed a novel screening equation for the diagnosis of urothelial carcinoma using d-asparagine in serum and estimated the glomerular filtration rate (eGFR). Serum d-asparagine levels adjusted for eGFR exhibited high performance in the diagnosis of UC (AUC-ROC, 0.869; sensitivity, 80.6 %; specificity, 82.7 %), even in early-stage UC (AUC-ROC: 0.859, sensitivity: 83.3 %, specificity: 82.3 %), which were previously misdiagnosed via urinary occult blood or urine cytology. This established strategy combined with urinary occult blood, improves diagnostic ability (sensitivity: 93.7 %, specificity: 70.1 %).
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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