Levels and functionality of Pacific Islanders' hybrid humoral immune response to BNT162b2 vaccination and delta/omicron infection: A cohort study in New Caledonia.

Autor: Inizan C; Dengue and Arboviroses - Research and Expertise Unit - Institut Pasteur in New Caledonia - Pasteur Network, Dumbéa-sur-Mer, New Caledonia., Courtot A; Provincial Office for Health and Social Action of the South Province (Direction Provinciale de l'Action Sanitaire et Sociale en Province Sud), Nouméa, New Caledonia., Sturmach C; National Reference Center for Respiratory Viruses, Institut Pasteur, Université Paris Cité, Paris, France.; Molecular Genetics of RNA Viruses Unit, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France., Griffon AF; Dengue and Arboviroses - Research and Expertise Unit - Institut Pasteur in New Caledonia - Pasteur Network, Dumbéa-sur-Mer, New Caledonia., Biron A; New Caledonia Territorial Hospital, Dumbéa-sur-Mer, New Caledonia., Bruel T; Antiviral Activities of Antibodies Group, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France.; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France.; Vaccine Research Institute, Créteil, France., Enouf V; National Reference Center for Respiratory Viruses, Institut Pasteur, Université Paris Cité, Paris, France.; Molecular Genetics of RNA Viruses Unit, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France., Demaneuf T; Social and Sanitary Agency of New Caledonia (Agence Sanitaire et Sociale de Nouvelle-Calédonie), Nouméa, New Caledonia., Munier S; Molecular Genetics of RNA Viruses Unit, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France., Schwartz O; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France.; Vaccine Research Institute, Créteil, France., Gourinat AC; New Caledonia Territorial Hospital, Dumbéa-sur-Mer, New Caledonia., Médevielle G; Provincial Office for Health and Social Action of the South Province (Direction Provinciale de l'Action Sanitaire et Sociale en Province Sud), Nouméa, New Caledonia., Jouan M; Dengue and Arboviroses - Research and Expertise Unit - Institut Pasteur in New Caledonia - Pasteur Network, Dumbéa-sur-Mer, New Caledonia., van der Werf S; National Reference Center for Respiratory Viruses, Institut Pasteur, Université Paris Cité, Paris, France.; Molecular Genetics of RNA Viruses Unit, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France., Madec Y; Epidemiology of Emerging Diseases, Institut Pasteur, Université de Paris, Paris, France., Albert-Dunais V; New Caledonia Specialized Hospital, Nouméa, New Caledonia., Dupont-Rouzeyrol M; Dengue and Arboviroses - Research and Expertise Unit - Institut Pasteur in New Caledonia - Pasteur Network, Dumbéa-sur-Mer, New Caledonia.
Jazyk: angličtina
Zdroj: PLoS medicine [PLoS Med] 2024 Sep 26; Vol. 21 (9), pp. e1004397. Date of Electronic Publication: 2024 Sep 26 (Print Publication: 2024).
DOI: 10.1371/journal.pmed.1004397
Abstrakt: Background: Pacific Islanders are underrepresented in vaccine efficacy trials. Few studies describe their immune response to COVID-19 vaccination. Yet, this characterization is crucial to re-enforce vaccination strategies adapted to Pacific Islanders singularities.
Methods and Findings: We evaluated the humoral immune response of 585 adults, self-declaring as Melanesians, Europeans, Polynesians, or belonging to other communities, to the Pfizer BNT162b2 vaccine. Anti-spike and anti-nucleoprotein IgG levels, and their capacity to neutralize SARS-CoV-2 variants and to mediate antibody-dependent cellular cytotoxicity (ADCC) were assessed across communities at 1 and 3 months post-second dose or 1 and 6 months post-third dose. All sera tested contained anti-spike antibodies and 61.3% contained anti-nucleoprotein antibodies, evidencing mostly a hybrid immunity resulting from vaccination and SARS-CoV-2 infection. At 1-month post-immunization, the 4 ethnic communities exhibited no significant differences in their anti-spike IgG levels (p value = 0.17, in an univariate linear regression model), in their capacity to mediate omicron neutralization (p value = 0.59 and 0.60, in an univariate logistic regression model at 1-month after the second and third dose, respectively) and in their capacity to mediate ADCC (p value = 0.069 in a multivariate linear regression model), regardless of the infection status. Anti-spike IgG levels and functionalities of the hybrid humoral immune response remained equivalent across the 4 ethnic communities during follow-up and at 6 months post-third dose.
Conclusions: Our study evidenced Pacific Islander's robust humoral immune response to Pfizer BNT162b2 vaccine, which is pivotal to re-enforce vaccination deployment in a population at risk for severe COVID-19.
Trial Registration: This trial has been register in ClinicalTrials.gov (ID: NCT05135585).
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Inizan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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