Multiple independent losses of crossover interference during yeast evolutionary history.

Autor: Dutta A; Université de Strasbourg, CNRS, GMGM UMR7156, Strasbourg, France., Dutreux F; Université de Strasbourg, CNRS, GMGM UMR7156, Strasbourg, France., Garin M; Université de Strasbourg, CNRS, GMGM UMR7156, Strasbourg, France., Caradec C; Université de Strasbourg, CNRS, GMGM UMR7156, Strasbourg, France., Friedrich A; Université de Strasbourg, CNRS, GMGM UMR7156, Strasbourg, France., Brach G; Université de Strasbourg, CNRS, GMGM UMR7156, Strasbourg, France., Thiele P; Université de Strasbourg, CNRS, GMGM UMR7156, Strasbourg, France., Gaudin M; CNRS UMR7258, INSERM U1068, Aix Marseille Université UM105, Institut Paoli-Calmettes, CRCM, Marseille, France., Llorente B; CNRS UMR7258, INSERM U1068, Aix Marseille Université UM105, Institut Paoli-Calmettes, CRCM, Marseille, France., Schacherer J; Université de Strasbourg, CNRS, GMGM UMR7156, Strasbourg, France.; Institut Universitaire de France (IUF), Paris, France.
Jazyk: angličtina
Zdroj: PLoS genetics [PLoS Genet] 2024 Sep 26; Vol. 20 (9), pp. e1011426. Date of Electronic Publication: 2024 Sep 26 (Print Publication: 2024).
DOI: 10.1371/journal.pgen.1011426
Abstrakt: Meiotic recombination is essential for the accurate chromosome segregation and the generation of genetic diversity through crossover and gene conversion events. Although this process has been studied extensively in a few selected model species, understanding how its properties vary across species remains limited. For instance, the ancestral ZMM pathway that generates interference-dependent crossovers has undergone multiple losses throughout evolution, suggesting variations in the regulation of crossover formation. In this context, we first characterized the meiotic recombination landscape and properties of the Kluyveromyces lactis budding yeast. We then conducted a comprehensive analysis of 29,151 recombination events (19, 212 COs and 9, 939 NCOs) spanning 577 meioses in the five budding yeast species Saccharomyces cerevisiae, Saccharomyces paradoxus, Lachancea kluyveri, Lachancea waltii and K. lactis. Eventually, we found that the Saccharomyces yeasts displayed higher recombination rates compared to the non-Saccharomyces yeasts. In addition, bona fide crossover interference and associated crossover homeostasis were detected in the Saccharomyces species only, adding L. kluyveri and K. lactis to the list of budding yeast species that lost crossover interference. Finally, recombination hotspots, although highly conserved within the Saccharomyces yeasts are not conserved beyond the Saccharomyces genus. Overall, these results highlight great variability in the recombination landscape and properties through budding yeasts evolution.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Dutta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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