Circulating levels of vitamins and risk of lymphoma: insights from a two-sample Mendelian randomization.

Autor: Rong YY; Department of Hematology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Liu PC; Department of Rheumatology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Huang XB; Department of Hematology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China., Chen GA; Department of Hematology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jazyk: angličtina
Zdroj: Expert review of hematology [Expert Rev Hematol] 2024 Sep 26, pp. 1-7. Date of Electronic Publication: 2024 Sep 26.
DOI: 10.1080/17474086.2024.2410009
Abstrakt: Background: To explore the genetic causal association between lymphoma and the circulating levels of vitamins through Mendelian randomization (MR).
Research Design and Methods: We performed MR analysis using publicly available genome-wide association study (GWAS) summary data. Seven indicators related to the circulating levels of vitamins (vitamin D, vitamin C, vitamin B6, vitamin B12, folic acid, vitamin E, and carotene) served as exposures, while lymphoma was the outcome. The genetic causal association between these circulating levels of vitamin indicators and lymphoma was assessed using the inverse variance weighted (IVW) method.
Results: Based on IVW method, vitamin B12 (OR = 0.48; 95% CI: 0.28-5.19; p  = 0.018) and folic acid (OR = 0.62; 95% CI: 0.40-0.96; p  = 0.032) both showed substantial evidence of a relationship with lymphoma. Moreover, the Weighted median method similarly indicated potential evidence of an association between vitamin B12 (OR = 0.40; 95% CI: 0.18-0.90; p  = 0.027) and lymphoma. The Simple mode, and Weighted mode methods showed no potential genetic causal association ( p  > 0.05 in the two analyses).
Conclusions: This study suggests a potential association between folic acid and vitamin B12 and lymphoma. Further research is required to assess the reproducibility of this finding in different contexts and to gain deeper insights into the potential underlying mechanisms.
Databáze: MEDLINE
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