Widespread Adaptive Introgression of Major Histocompatibility Complex Genes across Vertebrate Hybrid Zones.

Autor:	Gaczorek T; Institute of Environmental Sciences, Faculty of Biology, Jagiellonian University, Kraków, Poland., Dudek K; Institute of Environmental Sciences, Faculty of Biology, Jagiellonian University, Kraków, Poland., Fritz U; Museum of Zoology (Museum für Tierkunde), Senckenberg Dresden, Dresden, Germany., Bahri-Sfar L; Biodiversité, Parasitologie et Ecologie des Ecosystèmes Aquatiques, Faculté des Sciences de Tunis, Univ de Tunis El Manar, Tunis, Tunisia., Baird SJE; Institute of Vertebrate Biology of the Czech Academy of Sciences, Brno, Czech Republic., Bonhomme F; Institut des Sciences de l'Evolution, Université de Montpellier, Montpellier, France., Dufresnes C; Institut de Systématique, Evolution, Biodiversité (ISYEB), Muséum National d'Histoire Naturelle, CNRS, Sorbonne Université, EPHE, Université des Antilles, Paris, France., Gvoždík V; Institute of Vertebrate Biology of the Czech Academy of Sciences, Brno, Czech Republic.; Department of Zoology, National Museum of the Czech Republic, Prague, Czech Republic., Irwin D; Biodiversity Research Centre and Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada., Kotlík P; Laboratory of Molecular Ecology, Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, Liběchov, Czech Republic., Marková S; Laboratory of Molecular Ecology, Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, Liběchov, Czech Republic., McGinnity P; School of Biological, Earth and Environmental Sciences, University College Cork, Cork, Ireland., Migalska M; Institute of Environmental Sciences, Faculty of Biology, Jagiellonian University, Kraków, Poland., Moravec J; Department of Zoology, National Museum of the Czech Republic, Prague, Czech Republic., Natola L; Biodiversity Research Centre and Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada., Pabijan M; Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Kraków, Poland., Phillips KP; Laboratory of Molecular Ecology, Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, Liběchov, Czech Republic.; Canadian Rivers Institute, University of New Brunswick, Fredericton, New Brunswick, Canada., Schöneberg Y; Senckenberg Biodiversity and Climate Research Centre (BiK-F), Frankfurt am Main, Germany.; Institute for Ecology, Evolution and Diversity, Goethe University, Frankfurt am Main, Germany., Souissi A; Biodiversité, Parasitologie et Ecologie des Ecosystèmes Aquatiques, Faculté des Sciences de Tunis, Univ de Tunis El Manar, Tunis, Tunisia.; MARBEC, Univ Montpellier, 34000 Montpellier, France., Radwan J; Institute of Environmental Biology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland., Babik W; Institute of Environmental Sciences, Faculty of Biology, Jagiellonian University, Kraków, Poland.
Jazyk:	angličtina
Zdroj:	Molecular biology and evolution [Mol Biol Evol] 2024 Oct 04; Vol. 41 (10).
DOI:	10.1093/molbev/msae201
Abstrakt:	Interspecific introgression is a potentially important source of novel variation of adaptive significance. Although multiple cases of adaptive introgression are well documented, broader generalizations about its targets and mechanisms are lacking. Multiallelic balancing selection, particularly when acting through rare allele advantage, is an evolutionary mechanism expected to favor adaptive introgression. This is because introgressed alleles are likely to confer an immediate selective advantage, facilitating their establishment in the recipient species even in the face of strong genomic barriers to introgression. Vertebrate major histocompatibility complex genes are well-established targets of long-term multiallelic balancing selection, so widespread adaptive major histocompatibility complex introgression is expected. Here, we evaluate this hypothesis using data from 29 hybrid zones formed by fish, amphibians, squamates, turtles, birds, and mammals at advanced stages of speciation. The key prediction of more extensive major histocompatibility complex introgression compared to genome-wide introgression was tested with three complementary statistical approaches. We found evidence for widespread adaptive introgression of major histocompatibility complex genes, providing a link between the process of adaptive introgression and an underlying mechanism. Our work identifies major histocompatibility complex introgression as a general mechanism by which species can acquire novel, and possibly regain previously lost, variation that may enhance defense against pathogens and increase adaptive potential. Competing Interests: Conflict of Interest The authors declare no conflicts of interest. (© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.)
Databáze:	MEDLINE
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