| Autor: |
Mohammed Laid Tlili; Department of Cellular and Molecular Biology, El Oued University, N48, El Oued 39000, Algeria. tlili-laid@univ-eloued.dz., Ibtissam Laib; ibtissambiochimie95@gmail.com., Khadidja Salemi; monsof2001@gmail.com., Imane Chetehouna; tlilirawan98@gmail.com., Ines Ben Moussa; besseimohcen17@gmail.com. |
| Jazyk: |
angličtina |
| Zdroj: |
Acta chimica Slovenica [Acta Chim Slov] 2024 Aug 27; Vol. 71 (3), pp. 492-499. Date of Electronic Publication: 2024 Aug 27. |
| DOI: |
10.17344/acsi.2024.8748 |
| Abstrakt: |
The purpose of this study is to determine the phytochemical content and biological activities of the Astragalus gombo (endemic specie). While identification and quantification of individual secondary metabolites were performed by analysis HPLC. Antioxidant (DPPH and FRAP), anti-inflammatory, anti-hemolytic and antibacterial activities were evaluated. For analysis HPLC, we obtained 65 peaks and identified 6 major bioactive compounds. The total concentration in polyphenols, flavonoids and condensed tannins varied respectively from 66.306±0.88 mg GA eq/g, 34.312±1.4 mg Q eq/g and 5.343±2.74 mg Ca eq/g. In terms of antioxidant activity, we found that this extract had high inhibitory ratios equivalent to IC50=62.813±0.006 µg/mL for DPPH and IC50=19.375±0.041 µg/mL for FRAP. A high anti-inflammatory activity was estimated at 1615.81µg/mL, and a weak anti-hemolytic activity, the other hand the antibacterial activity is somewhat moderate against the five strains studied. This study demonstrated that the aqueous extract of A. gombo from El Oued region has tremendous antioxidant, anti-inflammatory and antibacterial abilities. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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