Population-based prevalence of self-reported pediatric diabetes and screening for undiagnosed type 2 diabetes in Chinese children in years 2017-2019, a cross-sectional study.

Autor:	Wu W; Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Regional Center for Children's Health, 3333 Binsheng Road, 310051, Hangzhou, Zhejiang, China., Zhang JW; Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Regional Center for Children's Health, 3333 Binsheng Road, 310051, Hangzhou, Zhejiang, China.; Shaoxing Women and Children Hospital, 321000, Shaoxing, Zhejiang, China., Li Y; Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Regional Center for Children's Health, 3333 Binsheng Road, 310051, Hangzhou, Zhejiang, China.; Research Institute of McGill University Health Centre, 1001 Decarie Boulevard, Montreal, QC, Canada., Huang K; Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Regional Center for Children's Health, 3333 Binsheng Road, 310051, Hangzhou, Zhejiang, China., Chen RM; Fuzhou Children's Hospital of Fujian Province, 350005, Fuzhou, Fujian, China., Maimaiti M; The First Affiliated Hospital of Xinjiang Medical University, 830011, Wulumuqi, Xinjiang Uygur Autonomous Region, China., Luo JS; The Maternity Hospital of Guangxi Zhuang Autonomous Region, 537406, Nanning, Guangxi Zhuang Autonomous Region, China., Chen SK; The Second Affiliated Hospital of Guangxi Medical University, 537406, Nanning, Guangxi Zhuang Autonomous Region, China., Wu D; Beijing Children's Hospital, Capital Medical University, 100045, Beijing, China., Zhu M; The Children's Hospital of Chongqing Medical University, 400014, Chongqing, China., Wang CL; The First Affiliated Hospital, Zhejiang University School of Medicine, 310053, Hangzhou, Zhejiang, China., Su Z; Shenzhen Children's Hospital, 518034, Shenzhen, Guangdong, China., Liang Y; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, China., Yao H; Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, China., Wei HY; Children's Hospital Affiliated Zhengzhou University, 450066, Zhengzhou, Henan, China., Zheng RX; Tianjin Medical University General Hospital, 300052, Tianjin, China., Du HW; The First Bethune Hospital of Jilin University, 130061, Changchun, Jilin, China., Luo FH; Children's Hospital of Fudan University, 200433, Shanghai, China., Li P; Shanghai Children's Hospital, Shanghai Jiao Tong University, 200433, Shanghai, China., Wang E; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27708, USA., Polychronakos C; Research Institute of McGill University Health Centre, 1001 Decarie Boulevard, Montreal, QC, Canada., Fu JF; Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Regional Center for Children's Health, 3333 Binsheng Road, 310051, Hangzhou, Zhejiang, China.
Jazyk:	angličtina
Zdroj:	The Lancet regional health. Western Pacific [Lancet Reg Health West Pac] 2024 Sep 18; Vol. 52, pp. 101206. Date of Electronic Publication: 2024 Sep 18 (Print Publication: 2024).
DOI:	10.1016/j.lanwpc.2024.101206
Abstrakt:	Background: The worldwide geographical and temporal variation in the prevalence of diabetes represents a challenge, but also an opportunity for gaining etiological insights. Encompassing the bulk of East Asians, a large and distinct proportion of the world population, China can be a source of valuable epidemiological insights for diabetes, especially in early life, when pathophysiology begins. We carried out a nationwide, epidemiological survey of Prevalence and Risk of Obesity and Diabetes in Youth (PRODY) in China, from 2017 to 2019, to estimate the population-based prevalence of diagnosed pediatric diabetes and screen for undiagnosed pediatric type 2 diabetes (T2D). Methods: PRODY was a nation-wide, school population-based, cross-sectional, multicenter survey by questionnaire, fasting urine glucose test and simple oral glucose tolerance test (s-OGTT), among a total number of 193,801 general-population children and adolescents (covered a pediatric population of more than 96.8 million), aged 3-18, from twelve provinces across China. The prevalence of the self-reported pediatric diabetes, the proportion of subtypes, the crude prevalence of undiagnosed T2D and prediabetes in general juvenile population and the main risk factors of type 1 (T1D) and type 2 (T2D) diabetes had been analyzed in the study. Findings: The prevalence of all self-reported pediatric diabetes was estimated at 0.62/1000 (95% CI: 0.51-0.74), with T1D at 0.44/1000 (95% CI: 0.35-0.54) and T2D at 0.18/1000 (95% CI: 0.13-0.25). For undiagnosed T2D, the crude prevalence was almost ten-fold higher, at 1.59/1000, with an estimated extra 28.45/1000 of undiagnosed impaired glucose tolerance (IGT) and 53.74/1000 of undiagnosed impaired fasting glucose (IFG) by s-OGTT screening. Maternal diabetes history is the major risk factors for all subtypes of pediatric diabetes in China. Interpretation: The PRODY study provides the first population-based estimate of the prevalence of pediatric diabetes China and reveals a magnitude of the problem of undiagnosed pediatric T2D. We propose a practical screening strategy by s-OGTT to address this serious gap. Funding: The National Key Research and Development Programme of China, Key R&D Program of Zhejiang, the National Natural Science Foundation of China and the Zhejiang Provincial Key Disciplines of Medicine, Key R&D Program Projects in Zhejiang Province. Competing Interests: The authors have no conflict of interest to disclose. (© 2024 The Authors.)
Databáze:	MEDLINE
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