Guidance to inform research recruitment processes for studies involving critically ill patients.

Autor:	Woolfall K; Department of Public Health, Policy and Systems, Institute of Population Health, University of Liverpool, Liverpool, UK., Paddock K; Faculty of Health and Education, School of Childhood, Youth and Education Studies, Manchester Metropolitan University, Manchester, UK., Watkins M; National Collaborating Centre for Mental Health, Royal College of Psychiatrists, London, UK., Kearney A; Department of Health Data Science, Institute of Population Health, University of Liverpool, Liverpool, UK., Neville K; Department of Health Data Science, Institute of Population Health, University of Liverpool, Liverpool, UK., Frith L; Centre for Social Ethics and Policy, University of Manchester, Manchester, UK., Welters I; Institute of Life Course and Medical Science, University of Liverpool and Department of Critical Care, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Gamble C; Department of Health Data Science, Institute of Population Health, University of Liverpool, Liverpool, UK., Trinder J; South Eastern Health & Social Services Trust, Ulster Hospital, Belfast, UK., Pattison N; University of Hertfordshire and East & North Herts NHS Trust, Stevenage, UK., White C; ICU Steps, London, UK., Brett S; Imperial College London and Imperial College Healthcare NHS Trust, London, UK., Dilworth S; ICU Steps, PPI Partner, UK., Ross M; PPI Partner, UK., Mouncey P; Intensive Care National Audit & Research Centre, London, UK., Rowan K; Intensive Care National Audit & Research Centre, London, UK., Dawson A; Centre for Biomedical Ethics, National University of Singapore, Singapore., Collet C; Health Research Authority, London, UK., Walsh T; University of Edinburgh, Scotland, UK., Young B; Department of Public Health, Policy and Systems, Institute of Population Health, University of Liverpool, Liverpool, UK.
Jazyk:	angličtina
Zdroj:	Journal of the Intensive Care Society [J Intensive Care Soc] 2024 Feb; Vol. 25 (1), pp. 95-101. Date of Electronic Publication: 2023 Sep 08.
DOI:	10.1177/17511437231197293
Abstrakt:	Clinical research in intensive care units (ICUs) is essential for improving treatments for critically ill patients. However, invitations to participate in clinical research in this situation pose numerous challenges. Studies are frequently initiated within a narrow time window when patients are often unconscious and unable to consent. Consultations or consent discussions must therefore be held with consultees or representatives, usually the patient's relatives. Conversations about research participation in this setting may be difficult, as relatives are often overwhelmed and may feel uneasy about making decisions on behalf of their relatives. In some circumstances, legislation allows doctors to act as consultees or representatives to enrol patients in research. However, there is little good quality evidence on UK stakeholders' perspectives to inform how recruitment is carried out in ICU studies. The Perspectives Study collected evidence on the views of over 1400 stakeholders, including patients, relatives and healthcare practitioners, many of whom had first-hand experience of ICU treatment and research. This evidence was used to inform good practice guidance on recruitment of critically ill patients to research. Established social science methods and empirical ethics were employed to reflect the interests of stakeholders and justify recommendations. This guidance aims to bridge the gap between the legal frameworks and the realities of ICU studies and to ensure that research recruitment processes reflect the views of patients and families. Researchers and an expert Advisory Group brought different perspectives to interpreting the evidence to develop the guidance. In this article we present guidance for future ICU studies. Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Intensive Care Society 2023.)
Databáze:	MEDLINE
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