Determinants of HBeAg loss during follow-up of a multiethnic pediatric cohort.

Autor: Mutimer D; Liver and Hepatobiliary Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, England.; Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, England., Atabani SF; United Kingdom Health Security Agency (UKHSA), Birmingham, UK.; Virology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, England., Brown M; Liver Unit, Birmingham Children's Hospital, Birmingham, England., Logan J; Liver Unit, Birmingham Children's Hospital, Birmingham, England., Kelgeri C; Liver Unit, Birmingham Children's Hospital, Birmingham, England.
Jazyk: angličtina
Zdroj: Journal of medical virology [J Med Virol] 2024 Oct; Vol. 96 (10), pp. e29936.
DOI: 10.1002/jmv.29936
Abstrakt: Hepatitis B e antigen (HBeAg) loss is a key event in the natural history of chronic hepatitis B virus infection. The rate and determinants of HBeAg loss depend upon cohort characteristics at baseline. Few studies have examined the age-dependent rate, and none have examined the effect of patient sex and ethnicity on the age-dependant rate. The study of age-dependent rates requires the identification and long-term follow-up of a pediatric cohort. We have studied the age-dependent rate of HBeAg loss, and the rate of HBeAg loss measured from baseline, in a multi-ethnic cohort of 454 pediatric patients. During observation, HBeAg loss was observed in 121/303 (39.9%) HBeAg-positive patients. The rate of HBeAg loss was greater in the second versus the first and third decades of life. The age-related rate of HBeAg loss was clearly affected by patient sex and ethnicity, with earlier loss observed for males and for White versus both South Asian and Chinese ethnicities. When measured from baseline, Chinese patients had a slower rate of HBeAg loss in comparison with White patients. In multivariate analysis of HBeAg loss during prolonged follow-up, male sex, older age, and White ethnicity were associated with HBeAg loss, but antiviral treatment was not.
(© 2024 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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