Seroma incidence and risk factors in women undergoing mastectomies as surgical breast cancer treatment.

Autor: Fabro EAN; Physiotherapy Service, Cancer Hospital III, National Cancer Institute, Visconde de Santa Isabel Street, 274 - Vila Isabel, Rio de Janeiro, 20560-120, Brazil. efabro@inca.gov.br., Costa RM; Physiotherapy Service, Cancer Hospital III, National Cancer Institute, Visconde de Santa Isabel Street, 274 - Vila Isabel, Rio de Janeiro, 20560-120, Brazil., Fernandes MC; Physiotherapy Service, Cancer Hospital III, National Cancer Institute, Visconde de Santa Isabel Street, 274 - Vila Isabel, Rio de Janeiro, 20560-120, Brazil., Ximenes MA; Physiotherapy Service, Cancer Hospital III, National Cancer Institute, Visconde de Santa Isabel Street, 274 - Vila Isabel, Rio de Janeiro, 20560-120, Brazil., Nogueira DA; Institute of Exact Sciences, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil., Soares NB; Physiotherapy Service, Cancer Hospital III, National Cancer Institute, Visconde de Santa Isabel Street, 274 - Vila Isabel, Rio de Janeiro, 20560-120, Brazil., Thuler LCS; Clinical Epidemiology Program, National Cancer Institute, Rio de Janeiro, Brazil., Bergmann A; Clinical Epidemiology Program, National Cancer Institute, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2024 Sep 25; Vol. 32 (10), pp. 688. Date of Electronic Publication: 2024 Sep 25.
DOI: 10.1007/s00520-024-08881-w
Abstrakt: Introduction: Seroma is the most common early complication following surgical breast cancer treatment. Its development is associated with pain, scar complications, adjuvant therapy delays, the need for outpatient visits, and increased care costs.
Objective: Assess seroma incidence and risk factors in women undergoing mastectomies.
Method: This study comprises a prospective cohort encompassing women aged 18 or over undergoing mastectomies as a breast cancer treatment. Patients underwent physiotherapy on the 1st, 7th, and 30th postoperative days for kinetic-functional, skin, and wound healing assessments and were attended to by nurses for surgical wound care, draining liquid on the 7th, 14th, and 21st postoperative days. Seroma was defined as the presence of local fluctuations requiring puncture, regardless of the punctured volume.
Results: A total of 249 women were evaluated, with a mean age of 57.5 (SD = 11.8). A total of 77.1% were classified as overweight or obese, 60.2% were hypertensive, 21.3% were diabetic, 66.7% underwent neoadjuvant chemotherapy and 62.7% underwent axillary lymphadenectomies. Seroma incidence was 71.1%, requiring, on average, two aspiration punctures until condition resolution. Overweight or obese women and those who underwent axillary lymphadenectomies exhibited 1.92- and 2.06-fold higher risk for seroma development (OR = 1.92; 95% CI 1.02-3.61; p = 0.042; and OR = 2.06; 95% CI 1.17-3.63; p = 0.012), respectively.
Conclusion: Seroma incidence was very high. Being overweight or obese and undergoing axillary lymphadenectomy comprise independent seroma development risk factors. This study is part of a randomized clinical trial evaluating the effectiveness of applying compressive taping to prevent post-mastectomy seroma, which was approved by the Brazilian National Cancer Institute, Research Ethics Committee (2,774,824), and it is registered in the ClinicalTrials.gov (NCT04471142, on July 15, 2020).
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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