AFP-DIAM Score to Predict Survival in Patients with Hepatocellular Carcinoma Before TACE: A French Multicenter Study.

Autor: Rebillard E; Médecine Digestive et Hépato-Biliaire, Centre Hospitalier Universitaire de Clermont-Ferrand, 1 Place Lucie et Raymond Aubrac, 63003, Clermont-Ferrand Cedex 1, France., De Abreu N; Radiologie, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France., Buchard B; Médecine Digestive et Hépato-Biliaire, Centre Hospitalier Universitaire de Clermont-Ferrand, 1 Place Lucie et Raymond Aubrac, 63003, Clermont-Ferrand Cedex 1, France., Muti L; Médecine Digestive et Hépato-Biliaire, Centre Hospitalier Universitaire de Clermont-Ferrand, 1 Place Lucie et Raymond Aubrac, 63003, Clermont-Ferrand Cedex 1, France., Boulin M; Pharmacie, Centre Hospitalier Universitaire de Dijon, Dijon, France., Pereira B; Direction de la Recherche Clinique et Innovation, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France., Magnin B; Radiologie, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France., Abergel A; Médecine Digestive et Hépato-Biliaire, Centre Hospitalier Universitaire de Clermont-Ferrand, 1 Place Lucie et Raymond Aubrac, 63003, Clermont-Ferrand Cedex 1, France. aabergel@chu-clermontferrand.fr.; Radiologie, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France. aabergel@chu-clermontferrand.fr.; Pharmacie, Centre Hospitalier Universitaire de Dijon, Dijon, France. aabergel@chu-clermontferrand.fr.; Direction de la Recherche Clinique et Innovation, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France. aabergel@chu-clermontferrand.fr.; Université Clermont Auvergne, CHU, CNRS, Clermont Auvergne INP, Institut Pascal, 63000, Clermont-Ferrand, France. aabergel@chu-clermontferrand.fr.
Jazyk: angličtina
Zdroj: Digestive diseases and sciences [Dig Dis Sci] 2024 Nov; Vol. 69 (11), pp. 4259-4267. Date of Electronic Publication: 2024 Sep 25.
DOI: 10.1007/s10620-024-08639-8
Abstrakt: Background: Transarterial chemoembolization (TACE) is recommended as a palliative treatment for patients of the B stage of the Barcelona Clinic Liver Cancer (BCLC) classification.
Aims: To identify clinical, biological, and radiological predictors of survival in patients undergoing TACE and develop a pre-therapeutic prognostic score.
Methods: 191 adult cirrhotic patients treated for HCC with TACE at the University Hospital (UH) of Clermont-Ferrand (France) from 2007-2017 were retrospectively included. We investigated the impact of baseline liver function, patient characteristics, and tumor burden on overall survival and developed a prognostic score.
Results: Patients had a median age of 66 years and 126 patients were Child A. The AFP-DIAM score distinguishes two groups with a significant difference in survival time (median OS 28.3 months in patients with a score = 0 versus 17.7 months in patients with a score > 0). AFP-DIAM was validated on an external cohort, is well calibrated, and has the best discrimination capacity (C-index) as compared to NIACE, HAP, STATE, and SIX TO TWELVE. AFP-DIAM and SIX TO TWELVE are the more easy-to-use scores. When AFP-DIAM and the SIX TO TWELVE scores were tested in the same statistical model, results confirmed a better AFP-DIAM performance.
Conclusions: The AFP-DIAM is an easy-to-use score which allows to distinguish two groups with different prognosis before the first TACE session. Its use could provide further support to BCLC system to guide the therapeutic strategy of patients with HCC.
Competing Interests: Declarations Conflict of interest All authors have no potential conflict of interests related to this article to declare.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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