Synthesis and antibacterial activity of silver doped zinc sulfide/chitosan bionanocomposites: A new frontier in biomedical applications.

Autor: Farahani MMH; Faculty of Materials and Metallurgical Engineering, Semnan University, Semnan, Iran., Hajiebrahimi M; Faculty of Materials and Metallurgical Engineering, Semnan University, Semnan, Iran., Alamdari S; Department of Nanotechnology, Faculty of New Sciences and Technologies, Semnan University, Semnan, Iran. Electronic address: s.alamdari@semnan.ac.ir., Najafzadehkhoee A; Joint Glass Centre of the IIC SAS, TnUAD and FChFT STU, Študentská 2, Trenčín 91150, Slovak Republic., Khounsaraki GM; Institute of Materials Research, Slovak academy of science, Kosice, Slovakia., Agheb M; Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Medical Technologies, Isfahan University of Medical Sciences, Isfahan, Iran., Kostiuk V; Institute of Materials Research, Slovak academy of science, Kosice, Slovakia., Puškárová A; Institute of Molecular Biology, Slovak Academy of Sciences, Dúbravská Cesta 21, Bratislava 84551, Slovakia., Bučková M; Institute of Molecular Biology, Slovak Academy of Sciences, Dúbravská Cesta 21, Bratislava 84551, Slovakia., Pangallo D; Institute of Molecular Biology, Slovak Academy of Sciences, Dúbravská Cesta 21, Bratislava 84551, Slovakia., Hvizdoš P; Institute of Materials Research, Slovak academy of science, Kosice, Slovakia., Mirzaee O; Faculty of Materials and Metallurgical Engineering, Semnan University, Semnan, Iran. Electronic address: o_mirzaee@semnan.ac.ir.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Nov; Vol. 280 (Pt 4), pp. 135934. Date of Electronic Publication: 2024 Sep 23.
DOI: 10.1016/j.ijbiomac.2024.135934
Abstrakt: Numerous microbial species have caused infectious diseases worldwide, which have become a social burden and a menace to the community. So, there is a need to develop antimicrobial materials and specialized materials for biomedical applications. In the present investigation, we report the simple synthesis, the physicochemical, and antibacterial activity of Silver doped zinc sulfide (ZnS: Ag) capped with Chitosan (CS) to produce ZnS: Ag/CS bionanocomposites (BNCs). The prepared BNCs was evaluated by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) mapping, and UV-Vis spectroscopy. According to the XRD results, ZnS: Ag/CS particles with semicrystalline chitosan/hexagonal ZnS phase structures and an average crystallite size in the range of 30-40 nm was formed. According to FESEM images, a spherical/hexagonal shape of ZnS: Ag particles embedded in the polymeric chitosan matrix. The colony counting method was employed to investigate the antibacterial activity on Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The results revealed that ZnS: Ag particles and ZnS: Ag/CS BNCs have stronger antibacterial activities than pure CS and ZnS. The reduction percentage of ZnS: Ag/CS BNCs against S. aureus and E. coli after 6 h of treatment was >99.9 % and 70 % respectively. These findings suggest that ZnS: Ag/CS BCs not only offer superior antimicrobial properties compared to individual ZnS and CS but also have great potential for advancing biomedical applications due to their enhanced antibacterial performance. The simplicity of the synthesis method and the use of non-toxic materials like chitosan make this a sustainable approach for developing antimicrobial agents, which is a key advantage of this study.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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