Discovery of metabolite from the insect-derived endophytic Penicillium chrysogenum and their COX-2 inhibitory activity.
| Autor: | Zhu CY; Institue for Inheritance-Based Innovation of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, School of Pharmacy, Shenzhen University Medical School, Shenzhen 518060, PR China., Luo Q; Clinical Lab, Shenzhen University General Hospital, Shenzhen 518055, PR China., Zhang ZW; Institue for Inheritance-Based Innovation of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, School of Pharmacy, Shenzhen University Medical School, Shenzhen 518060, PR China., Li YP; Institue for Inheritance-Based Innovation of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, School of Pharmacy, Shenzhen University Medical School, Shenzhen 518060, PR China., Han D; Institue for Inheritance-Based Innovation of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, School of Pharmacy, Shenzhen University Medical School, Shenzhen 518060, PR China., Yan YM; Institue for Inheritance-Based Innovation of Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, School of Pharmacy, Shenzhen University Medical School, Shenzhen 518060, PR China. Electronic address: yanym@szu.edu.cn. |
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| Jazyk: | angličtina |
| Zdroj: | Fitoterapia [Fitoterapia] 2024 Dec; Vol. 179, pp. 106238. Date of Electronic Publication: 2024 Sep 24. |
| DOI: | 10.1016/j.fitote.2024.106238 |
| Abstrakt: | Three new N-alkylated amino acid derivatives, penichrysoamides A-C (1-3), along with a new citric acid derivative, penichrysoacid A (4), a new chromanone lactone penichrysoacid B (5), and a new amide derivative, penichrysoamide D (6), as well as seven known benzamide derivatives (7-13), were isolated from the endophytic fungus Penicillium chrysogenum derived from the insect Periplaneta americana. The structures of these compounds, including their absolute configurations, were elucidated using spectroscopic and computational techniques. Biological evaluation revealed that compounds 8-13 exhibited significant COX-2 inhibitory activity, with IC Competing Interests: Declaration of competing interest The authors declare no conflicts of interest. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| Databáze: | MEDLINE |
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