Cardiac biomarker profiles in dogs with naturally occurring precapillary pulmonary hypertension.

Autor: Lichtenberger J; Department of Companion Animals, Atlantic Veterinary College, University of Prince Edward Island, 550 University Ave, Charlottetown, PE C1A 4P3, Canada. Electronic address: lichtenberger.j@hotmail.fr., Côté E; Department of Companion Animals, Atlantic Veterinary College, University of Prince Edward Island, 550 University Ave, Charlottetown, PE C1A 4P3, Canada., Forney SD; California Animal Hospital Veterinary Specialty Group, 1736 S Sepulveda Ave, Los Angeles, CA 90025, USA., Barrett KA; California Animal Hospital Veterinary Specialty Group, 1736 S Sepulveda Ave, Los Angeles, CA 90025, USA., Ettinger SJ; California Animal Hospital Veterinary Specialty Group, 1736 S Sepulveda Ave, Los Angeles, CA 90025, USA.
Jazyk: angličtina
Zdroj: Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology [J Vet Cardiol] 2024 Dec; Vol. 56, pp. 56-64. Date of Electronic Publication: 2024 Aug 30.
DOI: 10.1016/j.jvc.2024.08.007
Abstrakt: Introduction/objectives: This study evaluated circulating amino-terminal pro-B-type natriuretic peptide (NT-proBNP), amino-terminal pro-A-type natriuretic peptide (NT-proANP), and cardiac troponin I (cTnI) concentrations in dogs with precapillary pulmonary hypertension (Pre-PH) and control dogs with respiratory clinical signs but no Pre-PH.
Animals: Twenty-six dogs (17 affected, and nine controls) were involved in the study.
Materials and Methods: This was a sub-study of a large prospective single-center observational study. Dogs underwent blood sample collection, physical examination, and echocardiographic evaluation. Precapillary pulmonary hypertension was diagnosed when a calculated right ventricular-to-right atrial pressure gradient (RV:RA PG) measuring ≥40 mmHg was identified echocardiographically, barring right ventricular outflow obstruction and/or left-sided cardiac disease.
Results: Two, nine, and six dogs had mild, moderate, and severe Pre-PH, respectively. Plasma concentrations of NT-proBNP, NT-proANP, and cTnI were significantly higher in the affected group than in the control group (P=0.020, P=0.009, P=0.011, respectively). There was a positive correlation between RV:RA PG and NT-proBNP (r = 0.52), NT-proANP (r = 0.54), and cTnI (r = 0.67) concentrations.
Discussion: Precapillary pulmonary hypertension should be included in the differential diagnosis list of elevated cardiac biomarker concentrations in dogs with respiratory signs.
Study Limitations: Strict selection criteria reduced group sizes. There were rare missing data points. The diagnosis of Pre-PH was obtained from Doppler echocardiographic RV:RA PG. The disease process causing Pre-PH was not evaluated histopathologically.
Conclusions: Circulating cardiac biomarker concentrations are increased in dogs with Pre-PH and there is a positive correlation between RV:RA PG and NT-proBNP, NT-proANP, and cTnI concentrations.
Competing Interests: Conflict of Interest Statement The authors do not have any conflicts of interest to disclose.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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