Effect of Addition of Metal Oxide Nanoparticles on the Strength of Heat-Cured Denture Base Resins: Protocol for Systematic Review and Meta-Analysis of In Vitro Studies.

Autor:	Kaurani P; Department of Prosthodontics Crown and Bridge, Mahatma Gandhi Dental College and Hospital, Jaipur, India., Hindocha A; Department of Prosthodontics and Crown and Bridge, Sinhgad Dental College and Hospital, Pune, India., Porwal A; Department of Prosthetic Dentistry, College of Dentistry, Jazan University, Jazan, Saudi Arabia., Tambe A; Department of Prosthodontics Crown and Bridge, Sau Mathurabai Bhausaheb Thorat Institute of Dental Sciences and Research, Nashik, India., Price C; Albert S Cook Library, Towson University, Towson, MD, United States., Goel V; School of Public Health, University of Nevada Las Vegas, Las Vegas, NV, United States., Krasner H; Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV, United States., Khubchandani J; College of Health, Education, and Social Transformation, New Mexico State University, Las Cruces, NM, United States., Batra K; Department of Medical Education, Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV, United States.; Office of Research, Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV, United States.
Jazyk:	angličtina
Zdroj:	JMIR research protocols [JMIR Res Protoc] 2024 Sep 25; Vol. 13, pp. e59999. Date of Electronic Publication: 2024 Sep 25.
DOI:	10.2196/59999
Abstrakt:	Background: Metal oxide nanoparticle-reinforced polymethyl methacrylate (PMMA) has been shown to improve mechanical properties, such as strength. Different types of metal oxide nanoparticles have been used previously, but the comparative effect on the strength of heat-cured denture base resins remains unclear. Objective: This is a protocol for a systematic review and meta-analysis that will aim to pool evidence to compare and analyze the effects of the addition of different metal oxide nanoparticles, with varied sizes and concentrations, on the strength (flexural, impact, transverse, compressive tensile strength, and fracture toughness) of heat-cured PMMA. In addition, this review aims to analyze methodological factors, such as adherence to testing and sample-making guidelines, and the effects of surface treatments of the nanoparticles on the strength of heat-cured denture base resins. Methods: The protocol has been registered in the Open Science Framework. Search strategies to identify studies on the effect of metal oxide nanoparticles on the strength of heat-cured PMMA were developed by the subject matter expert in library science. Following this, a systematic search of 5 electronic databases (PubMed [NCBI], Scopus [Elsevier], Cochrane Library [Wiley], CINAHL Plus with Full Text [EBSCO], and Dimensions Free Web App) was conducted to retrieve in vitro studies published in English from January 2012 to October 2023. Along with this citation chasing, other online sources and gray literature were also searched. Furthermore, papers will be screened, and appropriate data elements will be extracted in a standardized manner. A risk-of-bias assessment will be performed using a modified Cochrane Risk of Bias Tool. A meta-analysis will be performed using a random-effects model. Results: Search in databases resulted in 1837 papers, of which 1752 were duplicates, leaving 85 records that were screened for titles and abstracts based on the eligibility criteria. A similar search run on other online sources identified 129 papers that will be further analyzed for inclusion. The study was initiated in November 2023 and research questions and search strategies were formulated. The proposed study is expected to be completed by December 2024. Conclusions: This systematic review will comprehensively analyze the effects of the incorporation of metal oxide nanoparticles in heat-cured denture base resins on the strength of the material. We anticipate gaining a deeper understanding of the effects and method of use of metal oxide nanoparticles to improve the strength of PMMA denture base resins. International Registered Report Identifier (irrid): PRR1-10.2196/59999. (©Pragati Kaurani, Amit Hindocha, Amit Porwal, Abhijit Tambe, Carrie Price, Vidhani Goel, Henry Krasner, Jagdish Khubchandani, Kavita Batra. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 25.09.2024.)
Databáze:	MEDLINE
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