Tubulointerstitial nephritis in children and adolescents.

Autor: Gurevich E; Pediatrics Department, Barzilai University Medical Center, Ashqelon, Israel. gurevichjeny@gmail.com.; Ben Gurion University of Negev, Faculty of Health Sciences, Beer Sheva, Israel. gurevichjeny@gmail.com., Landau D; Department of Nephrology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.; School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Jazyk: angličtina
Zdroj: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2024 Sep 25. Date of Electronic Publication: 2024 Sep 25.
DOI: 10.1007/s00467-024-06526-y
Abstrakt: The tubulointerstitial compartment comprises most of the kidney parenchyma. Inflammation in this compartment (tubulointerstitial nephritis-TIN) can be acute and resolves if the offending factor is withdrawn or may enter a chronic process leading to irreversible kidney damage. Etiologic factors differ, including different exposures, infections, and autoimmune and genetic tendency, and the initial damage can be acute, recurrent, or permanent, determining whether the acute inflammatory process will lead to complete healing or to a chronic course of inflammation leading to fibrosis. Clinical and laboratory findings of TIN are often nonspecific, which may lead to delayed diagnosis and a poorer clinical outcome. We provide a general review of TIN, with special mention of the molecular pathophysiological mechanisms of the associated kidney damage.
(© 2024. The Author(s), under exclusive licence to International Pediatric Nephrology Association.)
Databáze: MEDLINE
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