Ovarian reserve alteration in premenopausal women with systemic sclerosis.

Autor: Pecher AC; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Autoinflammatory Diseases, University Hospital Tübingen, Otfried-Mueller-Strasse 10, 72076, Tübingen, Germany., Henes JC; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Autoinflammatory Diseases, University Hospital Tübingen, Otfried-Mueller-Strasse 10, 72076, Tübingen, Germany. Joerg.Henes@med.uni-tuebingen.de.; University Hospital Tuebingen, Otfried-Mueller-Strasse 10, 72076, Tuebingen, Germany. Joerg.Henes@med.uni-tuebingen.de., Demin A; Eberhard-Karls-University, Tuebingen, Germany., Staufenberg EM; Department of Obstetrics and Gynecology, University Hospital Tübingen, Calwerstrasse 7, 72076, Tübingen, Germany., Henes M; Department of Obstetrics and Gynecology, University Hospital Tübingen, Calwerstrasse 7, 72076, Tübingen, Germany.
Jazyk: angličtina
Zdroj: Rheumatology international [Rheumatol Int] 2024 Dec; Vol. 44 (12), pp. 3087-3092. Date of Electronic Publication: 2024 Sep 25.
DOI: 10.1007/s00296-024-05724-z
Abstrakt: Anti-Muellerian hormone (AMH) is produced by the granulosa cells of ovarian follicles. It serves as a sensitive laboratory parameter for assessing ovarian reserve. A reduced ovarian reserve has been observed in patients with various autoimmune diseases. To compare serum levels of AMH as a surrogate parameter for ovarian reserve in female patients with systemic sclerosis compared to healthy controls and thereby assess fertility. In this single centre study from the University Hospital Tuebingen, Germany, we used serum samples to determine concentrations of AMH via an electrochemiluminescence immunoassay. We analysed 30 premenopausal female patients with systemic sclerosis and 30 age-matched healthy controls from 18 to 40 years. Patients who had received cyclophosphamide were excluded from this study. AMH levels were significantly reduced in patients with systemic sclerosis (955 ng/l versus 1.940 ng/L, p < 0.01). Interestingly, in contrast to healthy controls, we observed no significant correlation between age and AMH levels in patients. For women diagnosed with systemic sclerosis, especially at a younger age, regular assessment of AMH levels should be considered to improve guidance with regard to optimal pregnancy timepoint, fertility preservation and treatment options.
Competing Interests: Declarations. Conflict of interests: Ann-Christin Pecher received honoraria by Novartis, UCB, Boehringer Ingelheim. Joerg Henes received grant support for SSc studies by Miltenyi and NEOVI and honoraria for lectures by ABBVIE, Astra-Zeneca, BMS, GSK, Novartis, UCB, Boehringer Ingelheim; Pfizer, Johnson & Johnson; SOBI. All other authors stated no conflict of interest. Ethical standards: The study was approved by the local ethics committee of the Eberhard-Karls-University Tuebingen (IRB 454/2023BO2) and all participants gave their written informed consent.
(© 2024. The Author(s).)
Databáze: MEDLINE
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