| Autor: |
Shlapa Y; V. I. Vernadsky Institute of General & Inorganic Chemistry of the NAS of Ukraine, 32/34 Palladina Avenue, Kyiv 03142, Ukraine., Siposova K; Institute of Experimental Physics, Slovak Academy of Science, Watsonova 47, Kosice 040 01, Slovakia., Sarnatskaya V; R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, 45, Vasylkivska Street, Kyiv 03022, Ukraine., Drajnova M; Institute of Experimental Physics, Slovak Academy of Science, Watsonova 47, Kosice 040 01, Slovakia.; Institute of Chemistry, Faculty of Science, P.J. Safarik University in Kosice, Moyzesova 11, Kosice 040 01, Slovakia., Silvestre-Albero J; Laboratorio de Materiales Avanzados, Instituto Universitario de Materiales-Departamento de Química Inorgánica, University of Alicante, Ctra. San Vicente-Alicante s/n, Alicante E-03080, Spain., Lykhova O; R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, 45, Vasylkivska Street, Kyiv 03022, Ukraine., Maraloiu VA; National Institute of Materials Physics, 405A Atomistilor Street, Magurele 077125, Romania., Solopan SO; V. I. Vernadsky Institute of General & Inorganic Chemistry of the NAS of Ukraine, 32/34 Palladina Avenue, Kyiv 03142, Ukraine., Molcan M; Institute of Experimental Physics, Slovak Academy of Science, Watsonova 47, Kosice 040 01, Slovakia., Musatov A; Institute of Experimental Physics, Slovak Academy of Science, Watsonova 47, Kosice 040 01, Slovakia., Belous A; V. I. Vernadsky Institute of General & Inorganic Chemistry of the NAS of Ukraine, 32/34 Palladina Avenue, Kyiv 03142, Ukraine. |
| Abstrakt: |
Blending carbon particles (CPs) and nanoscale bioactive cerium dioxide is a promising approach for designing composites for biomedical applications, combining the sorption and antioxidant potentials of each individual component. To address this issue, it is crucial to assess the correlation between the components' ratio, physicochemical parameters, and biofunctionality of the composites. Thus, the current research was aimed at fabricating C@CeO 2 composites with different molar ratios and the examination of how the parameters of the composites affect their bioactivity. XRD, X-ray photoelectron spectroscopy, and electron microscopy data verified the formation of C@CeO 2 composites. CeO 2 nanoparticles (NPs) of 4-6 nm are highly dispersed on the surfaces of amorphous CPs. The presence of CeO 2 NPs on the carbon surface decreased its adsorption potential in a dose-dependent manner. Besides, the coexistence of carbon and CeO 2 in a single composite promotes some redox interactions between O-functionalities and Ce 3+ /Ce 4+ species, resulting in changes in the chemical state of the surface of the composites. These observations suggest the strong connection between these parameters and the biofunctionality of the composites. The presence of CeO 2 NPs on the surface of carbon led to a significant increase in the stability of the prepared composites in their aqueous suspensions. The enhancement of bioactivity of the newly prepared C@CeO 2 compared to bare carbon and CeO 2 was validated by testing their pseudomimetic (catalase/peroxidase-like and superoxide dismutase-like), antiamyloid, and radioprotective activities. |
