Description of the new HIV-1 intersubtype B/C circulating recombinant form (CRF146_BC) detected in Brazil.

Autor:	Oliveira RC; Universidade Federal da Bahia, Departamento de Bioquímica e Biofísica, Núcleo de Bioinformática, Salvador, BA, Brasil., Martin D; University of Cape Town, Institute of Infectious Disease and Molecular Medicine, Department of Integrative Biomedical Sciences, Computational Biology Group, Cape Town, South Africa., de Souza JSM; Universidade Federal da Bahia, Departamento de Bioquímica e Biofísica, Núcleo de Bioinformática, Salvador, BA, Brasil., Alcântara LCJ; Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Flavivírus, Rio de Janeiro, RJ, Brasil., Guimarães ML; Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de AIDS e Imunologia Molecular, Rio de Janeiro, RJ, Brasil., Brites C; Universidade Federal da Bahia, Complexo Hospitalar Prof Edgard Santos, Laboratório de Pesquisa em Infectologia, Salvador, BA, Brasil., Monteiro-Cunha JP; Universidade Federal da Bahia, Departamento de Bioquímica e Biofísica, Núcleo de Bioinformática, Salvador, BA, Brasil.
Jazyk:	angličtina
Zdroj:	Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 2024 Sep 23; Vol. 119, pp. e230214. Date of Electronic Publication: 2024 Sep 23 (Print Publication: 2024).
DOI:	10.1590/0074-02760230214
Abstrakt:	Background: The human immunodeficiency virus 1 (HIV-1) infections in Brazil are predominantly caused by two subtypes, B and C. Objectives: Here we present the characterisation of a novel HIV-1 recombinant form, indicating a new Brazilian CRF_BC, named CRF146_BC. Methods: RDP, JphMM and Simplot recombination tools were used to evaluate the mosaic pattern. Findings: In this work, we identified three HIV-1 nucleotide sequences previously classified as unique recombinant forms (URFs), plus one new partial genome sharing the same BC recombination pattern. The mosaic genome is almost entirely represented by the subtype C sequence, with a small subtype B recombination region in the pol gene, at the Integrase level. The phylogenetic analyses strongly indicate a common origin between the strains, which were isolated in Rio Grande do Sul, Rio de Janeiro and Bahia states. Main Conclusions: Thus, the new HIV-1 CRF146_BC is circulating in three different Brazilian regions: South, Southeast and Northeast.
Databáze:	MEDLINE
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