Exercise training in left ventricular assist device patients: Protocol of an individual participant data meta-analysis.

Autor: Kambič T; Faculty of Sport, University of Ljubljana, Ljubljana, Slovenia., Feuerstein A; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité (DHZC)-Medical Heart Centre of Charité and German Heart Institute Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany., Tran PT; Department of Medical Statistics, University of Göttingen Medical Centre, Göttingen, Germany., Friede T; Department of Medical Statistics, University of Göttingen Medical Centre, Göttingen, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany., Edelmann F; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité (DHZC)-Medical Heart Centre of Charité and German Heart Institute Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany., Lainscak M; Division of Cardiology, General Hospital Murska Sobota, Murska Sobota, Slovenia.; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Jazyk: angličtina
Zdroj: ESC heart failure [ESC Heart Fail] 2024 Sep 25. Date of Electronic Publication: 2024 Sep 25.
DOI: 10.1002/ehf2.15063
Abstrakt: Aims: Although left ventricular assist device (LVAD) implantation improves prognosis of advanced heart failure patients still suffer from impaired exercise capacity and quality of life (QoL). Exercise training may improve both; however, the available evidence about exercise training effects in LVAD patients remains inconclusive due to small and monocentric randomized controlled trials. This study aims to aggregate the individual participant data (IPD) to perform meta-analysis on the safety and efficacy of exercise training on exercise capacity and QoL over standard care in LVAD patients.
Methods: Randomized controlled trials comparing exercise training and standard care (no supervised training) will be identified through database searching. Corresponding authors of eligible randomized controlled trials will be invited to share IPD. All IPD will be checked, recalculated to validate findings in initial reports, merged in a single dataset and stored in a secured encrypted database server. The merged IPD will be screened for quality, risk of bias, and heterogeneity of the included trials. Random effects meta-analyses will be conducted using one-stage and two-stage approaches, in particular with a view to subgroup analyses.
Results: Based on findings of the individual randomized trials, we expected to obtain superior effects of exercise training on submaximal exercise capacity and QoL and similar effects on maximal aerobic capacity when compared with standard care.
Conclusions: Our study will be the first to harmonize IPD in meta-analysis to demonstrate the effects of exercise training on exercise performance and QoL over standard care in LVAD patients.
Prospero Registration Number: CRD42023480119.
(© 2024 The Author(s). ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)
Databáze: MEDLINE
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