Tracking multidrug resistant tuberculosis: a 30-year analysis of global, regional, and national trends.

Autor:	Song HW; Department of Infectious Diseases, Sanming First Hospital Affiliated to Fujian Medical University, Sanming, Fujian, China.; The Graduate School of Fujian Medical University, Fuzhou, Fujian, China.; Department of Hepatology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China., Tian JH; Department of Infectious Diseases, Sanming First Hospital Affiliated to Fujian Medical University, Sanming, Fujian, China., Song HP; Department of Infectious Diseases, Sanming First Hospital Affiliated to Fujian Medical University, Sanming, Fujian, China., Guo SJ; Department of Infectious Diseases, Sanming First Hospital Affiliated to Fujian Medical University, Sanming, Fujian, China.; The Graduate School of Fujian Medical University, Fuzhou, Fujian, China., Lin YH; Department of Infectious Diseases, Sanming First Hospital Affiliated to Fujian Medical University, Sanming, Fujian, China.; The Graduate School of Fujian Medical University, Fuzhou, Fujian, China., Pan JS; Department of Hepatology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.; Hepatology Research Institute, Fujian Medical University, Fuzhou, Fujian, China.; Fujian Clinical Research Center for Liver and Intestinal Diseases, Fuzhou, Fujian, China.
Jazyk:	angličtina
Zdroj:	Frontiers in public health [Front Public Health] 2024 Sep 10; Vol. 12, pp. 1408316. Date of Electronic Publication: 2024 Sep 10 (Print Publication: 2024).
DOI:	10.3389/fpubh.2024.1408316
Abstrakt:	Objectives: To provide valuable insights for targeted interventions and resource allocation, our analysis delved into the multifaceted burden, trends, risks, and projections of multi drug resistant tuberculosis (MDR-TB). Methods: This research employed data from the Global Burden of Disease (GBD) 2019 dataset, which used a comparative risk assessment to quantify the disease burden resulting from risk factors. Initially, this database was utilized to extract details concerning the disability-adjusted life years (DALYs), mortality, incidence, and the number of individuals afflicted by MDR-TB. Subsequently, regression analyses were conducted using the Joinpoint program to figure average annual percent change (AAPC) to ascertain the trend. Thirdly, the age-period-cohort model (APCM) was adopted to analyze evolutions in incidence and mortality. Finally, utilizing the Nordpred model within R software, we projected the incidence and mortality of MDR-TB from 2020 to 2030. Results: MDR-TB remained a pressing global health concern in regions with lower socio-demographic indexes (SDI), where the AAPC in DALYs topped 7% from 1990 to 2019. In 2019, the cumulative DALYs attributed to MDR-TB tallied up to 4.2 million, with India, the Russian Federation, and China bearing the brunt. Notably, the incidence rates have shown a steadfast presence over the past decade, and a troubling forecast predicts an uptick in these areas from 2020 to 2030. Additionally, the risk of contracting MDR-TB grew with advancing age, manifesting most acutely among men aged 40+ in lower SDI regions. Strikingly, alcohol consumption had been identified as a significant contributor, surpassing the impacts of smoking and high fasting plasma glucose, leading to 0.7 million DALYs in 2019. Conclusions: A robust strategy is needed to end tuberculosis (TB) by 2030, especially in lower SDI areas. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Song, Tian, Song, Guo, Lin and Pan.)
Databáze:	MEDLINE
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