Curcumin and Cognitive Function: A Systematic Review of the Effects of Curcumin on Adults With and Without Neurocognitive Disorders.

Autor:	Francis AJ; Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA., Sreenivasan C; Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA., Parikh A; Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA., AlQassab O; Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA., Kanthajan T; Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA., Pandey M; Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA., Nwosu M; Clinical Research, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Aug 25; Vol. 16 (8), pp. e67706. Date of Electronic Publication: 2024 Aug 25 (Print Publication: 2024).
DOI:	10.7759/cureus.67706
Abstrakt:	This systematic review investigates the effect of curcumin on neurocognitive exams and inflammatory serum biomarkers in adults 18 years and older. We search PubMed, Science Direct, Google Scholar, Cochrane Library, and Multidisciplinary Digital Publishing Institute. Modeling the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA), we screened 1,284 studies with the keywords "neurocognitive disorders," "dementia," "cognitive health," "serum biomarkers," and "curcumin." We use the revised Cochrane Risk-of-Bias tool (RoB2) and the Newcastle-Ottawa Scale to select 12 open-access full-text articles published within 20 years. We include clinical trials, randomized controlled trials (RCTs), cohort studies, and human studies, excluding nonhumans, other design types, and schizophrenia. Despite gastrointestinal side effects, studies found curcumin significantly improves working memory in the following adult groups: non-demented, metabolically impaired, cognitively impaired, mood impaired, and chemotherapy impaired. Study limitations include variable population characteristics and few trials employing intention-to-treat analysis, emphasizing the need for shared clinical decision-making before curcumin therapy. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Francis et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu