Latent profiles of global electrical heterogeneity: the Hispanic Community Health Study/Study of Latinos.

Autor:	Tereshchenko LG; Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, JJN3-01, Cleveland, OH 44195, USA.; Heart, Vascular & Thoracic Institute, Cleveland Clinic, 9500 Euclid Ave, JJN3-01, Cleveland, OH 44195, USA.; Department of Medicine, Cardiovascular Division, Johns Hopkins School of Medicine, Baltimore, MD, USA., Haq KT; Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, USA., Howell SJ; Section of Electrophysiology, Division of Cardiology, University of California San Francisco, San Francisco, CA, USA., Mitchell EC; Department of Surgery, Brown University School of Medicine, Providence, RI, USA., Martínez J; School of Medicine, Oregon Health & Science University, Portland, OR, USA., Hyde J; School of Medicine, Oregon Health & Science University, Portland, OR, USA., Briceno G; School of Medicine, Oregon Health & Science University, Portland, OR, USA., Pena J; School of Medicine, Oregon Health & Science University, Portland, OR, USA., Pocius E; School of Medicine, Oregon Health & Science University, Portland, OR, USA., Khan A; School of Medicine, Oregon Health & Science University, Portland, OR, USA., Soliman EZ; Epidemiological Cardiology Research Center, Division of Public Health Sciences and Department of Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, NC, USA., Lima JAC; Department of Medicine, Cardiovascular Division, Johns Hopkins School of Medicine, Baltimore, MD, USA., Kapadia SR; Heart, Vascular & Thoracic Institute, Cleveland Clinic, 9500 Euclid Ave, JJN3-01, Cleveland, OH 44195, USA., Misra-Hebert AD; Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, JJN3-01, Cleveland, OH 44195, USA., Kattan MW; Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, JJN3-01, Cleveland, OH 44195, USA., Kansal MM; Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA., Daviglus ML; Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA., Kaplan R; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, NY, USA.; Public Health Sciences Division, Fred Hutch Cancer Center, Seattle, WA, USA.
Jazyk:	angličtina
Zdroj:	European heart journal. Digital health [Eur Heart J Digit Health] 2024 Jul 08; Vol. 5 (5), pp. 611-621. Date of Electronic Publication: 2024 Jul 08 (Print Publication: 2024).
DOI:	10.1093/ehjdh/ztae048
Abstrakt:	Aims: Despite the highest prevalence of stroke, obesity, and diabetes across races/ethnicities, paradoxically, Hispanic/Latino populations have the lowest prevalence of atrial fibrillation and major Minnesota code-defined ECG abnormalities. We aimed to use Latent Profile Analysis in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) population to obtain insight into epidemiological discrepancies. Methods and Results: We conducted a cross-sectional analysis of baseline HCHS/SOL visit. Global electrical heterogeneity (GEH) was measured as spatial QRS-T angle (QRSTa), spatial ventricular gradient azimuth (SVGaz), elevation (SVGel), magnitude (SVGmag), and sum absolute QRST integral (SAIQRST). Statistical analysis accounted for the stratified two-stage area probability sample design. We fitted a multivariate latent profile generalized structural equation model adjusted for age, sex, ethnic background, education, hypertension, diabetes, smoking, dyslipidaemia, obesity, chronic kidney disease, physical activity, diet quality, average RR' interval, median beat type, and cardiovascular disease (CVD) to gain insight into the GEH profiles. Among 15 684 participants (age 41 years; 53% females; 6% known CVD), 17% had an increased probability of likely abnormal GEH profile (QRSTa 80 ± 27°, SVGaz -4 ± 21°, SVGel 72 ± 12°, SVGmag 45 ± 12 mVms, and SAIQRST 120 ± 23 mVms). There was a 23% probability for a participant of being in Class 1 with a narrow QRSTa (40.0 ± 10.2°) and large SVG (SVGmag 108.3 ± 22.6 mVms; SAIQRST 203.4 ± 39.1 mVms) and a 60% probability of being in intermediate Class 2. Conclusion: A substantial proportion (17%) in the Hispanic/Latino population had an increased probability of altered, likely abnormal GEH profile, whereas 83% of the population was resilient to harmful risk factors exposures. Competing Interests: Conflict of interest: none declared. (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
Databáze:	MEDLINE
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