The known and unknown of post-pump chorea: a case report on robust steroid responsiveness implicating occult neuroinflammation.

Autor:	Iqbal M; Department of Neurology, SUNY Upstate Medical University, Syracuse, NY, United States., Zaman M; Department of Neurology, SUNY Upstate Medical University, Syracuse, NY, United States., Ojha N; Department of Neurology, SUNY Upstate Medical University, Syracuse, NY, United States., Gau YA; Department of Neurology, SUNY Upstate Medical University, Syracuse, NY, United States.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, United States., Young EI; Department of Neurology, SUNY Upstate Medical University, Syracuse, NY, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Sep 10; Vol. 15, pp. 1458022. Date of Electronic Publication: 2024 Sep 10 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1458022
Abstrakt:	Post-pump chorea (PPC) is characterized by the development of choreiform movements following cardiopulmonary bypass (CPB) surgery. PPC occurs almost exclusively in children, and its pathophysiology remains unclear. Here we present an adult case of PPC after bovine aortic valve replacement (AVR) which exhibited dramatic and reproducible response to steroid, suggesting the presence of occult neuroinflammation. This observation suggests a novel underlying mechanism in certain subgroups of PPC, which is likely a heterogeneous condition to start with. Further research into the pathomechanisms of PPC could offer insights into managing this otherwise symptomatic control-only condition. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Iqbal, Zaman, Ojha, Gau and Young.)
Databáze:	MEDLINE
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