Revealing alterations in heart rate fluctuations during the progression of Chagas disease.
| Autor: | Defeo MM; Hospital Interzonal General de Agudos 'Prof. R. Rossi', La Plata, Argentina., Delaplace LA; Laboratorio de Salud Pública, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina., Goin JC; Centro de Estudios Farmacológicos y Botánicos (CEFyBO-CONICET-UBA) and II Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina., Tersigni C; Laboratorio de Salud Pública, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina., Garavaglia L; Centro de Investigaciones Opticas (CIOp-CCT La Plata. CONICET), La Plata, Argentina., Irurzun IM; Centro de Simulación Computacional para Aplicaciones Tecnológicas-Consejo Nacional de Investigaciones Científicas y Técnicas (CSC-CONICET), Buenos Aires, Argentina. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in medicine [Front Med (Lausanne)] 2024 Sep 10; Vol. 11, pp. 1438077. Date of Electronic Publication: 2024 Sep 10 (Print Publication: 2024). |
| DOI: | 10.3389/fmed.2024.1438077 |
| Abstrakt: | Introduction: The heart rate variability (HRV) continually evolves throughout life, reflecting modifications in the architecture of the sinoatrial node (SAN) and in the regulation of heart rate by the autonomic nervous system (ANS). Both can be considerably affected by Chagas disease, causing important changes in the complex nature of HRV. We aim to evaluate the ability of an index based on the false nearest neighbors method (FN10) to reflect these changes during disease progression. Methods: We perform a retrospective, descriptive, and cross-sectional study analyzing HRV time series of participants with Chagas disease. We determine the dependence of FN10 on age and sex in a healthy population, and then evaluate FN10 in individuals with Chagas disease. Results and Discussion: In the healthy population, FN10 has a scaling behavior with age, which is independent of sex. In Chagas disease, some individuals show FN10 values significantly above those seen in the healthy population. We relate the findings to the pathophysiological mechanisms that determine the progression of the disease. The results indicate that FN10 may be a candidate prognostic biomarker for heart disease. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Defeo, Delaplace, Goin, Tersigni, Garavaglia and Irurzun.) |
| Databáze: | MEDLINE |
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