A cutting-edge new framework for the pain management in children: nanotechnology.

Autor:	Starcea IM; Pediatrics Department, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania.; Nephrology Division, St. Mary's Emergency Children Hospital, Iasi, Romania., Lupu A; Pediatrics Department, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Nistor AM; Nephrology Division, St. Mary's Emergency Children Hospital, Iasi, Romania., Mocanu MA; Pediatrics Department, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Bogos RA; Pediatrics Department, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Azoicai A; Pediatrics Department, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Cira D; Nephrology Division, St. Mary's Emergency Children Hospital, Iasi, Romania., Beldie M; Nephrology Division, St. Mary's Emergency Children Hospital, Iasi, Romania., Lupu VV; Pediatrics Department, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Morariu ID; Faculty of Pharmacy, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Munteanu V; Faculty of Medical Bioengineering, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Tepordei RT; Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania., Ioniuc I; Pediatrics Department, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi, Romania.
Jazyk:	angličtina
Zdroj:	Frontiers in molecular neuroscience [Front Mol Neurosci] 2024 Sep 10; Vol. 17, pp. 1391092. Date of Electronic Publication: 2024 Sep 10 (Print Publication: 2024).
DOI:	10.3389/fnmol.2024.1391092
Abstrakt:	Pain is a subjective concept which is ever-present in the medical field. Health professionals are confronted with a variety of pain types and sources, as well as the challenge of managing a patient with acute or chronic suffering. An even bigger challenge is presented in the pediatric population, which often cannot quantify pain in a numerical scale like adults. Infants and small children especially show their discomfort through behavioral and physiological indicators, leaving the health provider with the task of rating the pain. Depending on the pathophysiology of it, pain can be classified as neuropathic or nociceptive, with the first being defined by an irregular signal processing in the nervous system and the second appearing in cases of direct tissue damage or prolonged contact with a certain stimulant. The approach is generally either pharmacological or non-pharmacological and it can vary from using NSAIDs, local anesthetics, opiates to physical and psychological routes. Unfortunately, some pathologies involve either intense or chronic pain that cannot be managed with traditional methods. Recent studies have involved nanoparticles with special characteristics such as small dimension and large surface area that can facilitate carrying treatments to tissues and even offer intrinsic analgesic properties. Pediatrics has benefited significantly from the application of nanotechnology, which has enabled the development of novel strategies for drug delivery, disease diagnosis, and tissue engineering. This narrative review aims to evaluate the role of nanotechnology in current pain therapy, with emphasis on pain in children. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Starcea, Lupu, Nistor, Mocanu, Bogos, Azoicai, Cira, Beldie, Lupu, Morariu, Munteanu, Tepordei and Ioniuc.)
Databáze:	MEDLINE
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