Typing of Vulvar Squamous Cell Carcinoma: Why it is Important?
| Autor: | Alfaraidi M; Department of Pathology and Laboratory Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, Canada., Gilks CB; Department of Pathology, Prince Sultan Military Medical Hospital, Riyadh, Saudi Arabia., Hoang L; Department of Pathology, Prince Sultan Military Medical Hospital, Riyadh, Saudi Arabia. |
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| Jazyk: | angličtina |
| Zdroj: | Advances in anatomic pathology [Adv Anat Pathol] 2025 Jan 01; Vol. 32 (1), pp. 20-29. Date of Electronic Publication: 2024 Sep 25. |
| DOI: | 10.1097/PAP.0000000000000466 |
| Abstrakt: | The classification of vulvar squamous cell carcinoma (VSCC), as in endometrial cancer, has shifted from the histology-based descriptors toward molecular-based identifiers. Recently, it has been reported that there are 3 genetically distinct and clinically significant subtypes of VSCC: HPV-associated VSCC, HPV-independent/p53 wild-type VSCC, and HPV-independent/p53-mutated VSCC. Each group has different prognostic implications as well as response to treatment, thus reinforcing the need for this 3-tier molecular classification. This molecular subtyping can easily be done on vulvar biopsies using p16 and p53 immunohistochemistry stains to further improve risk prediction and individualized treatment decisions, leading to better patient outcomes. Competing Interests: The authors have no funding or conflicts of interest to disclose. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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