Physiology, Pathophysiology and Clinical Relevance of D-Amino Acids Dynamics: From Neurochemistry to Pharmacotherapy.

Autor: Donoso MV; Pharmacology Laboratory, Department Biology, Faculty of Chemistry and Biology, Centro Desarrollo de Nanociencias y Nanotecnología (CEDENNA), Universidad de Santiago de Chile, Alameda, 3363, Santiago, Chile., Catalán-Salas V; Pharmacology Laboratory, Department Biology, Faculty of Chemistry and Biology, Centro Desarrollo de Nanociencias y Nanotecnología (CEDENNA), Universidad de Santiago de Chile, Alameda, 3363, Santiago, Chile., Pulgar-Sepúlveda R; Neural System Laboratory, Department Biology, Faculty of Chemistry and Biology, Universidad de Santiago de Chile, Alameda, 3363, Santiago, Chile., Eugenín J; Neural System Laboratory, Department Biology, Faculty of Chemistry and Biology, Universidad de Santiago de Chile, Alameda, 3363, Santiago, Chile., Huidobro-Toro JP; Pharmacology Laboratory, Department Biology, Faculty of Chemistry and Biology, Centro Desarrollo de Nanociencias y Nanotecnología (CEDENNA), Universidad de Santiago de Chile, Alameda, 3363, Santiago, Chile.
Jazyk: angličtina
Zdroj: Chemical record (New York, N.Y.) [Chem Rec] 2024 Oct; Vol. 24 (10), pp. e202400013. Date of Electronic Publication: 2024 Sep 24.
DOI: 10.1002/tcr.202400013
Abstrakt: Over three decades ago, two independent groups of investigators identified free D-aspartic and later D-serine in specific brain nuclei and endocrine glands. This finding revealed a novel, non-proteinogenic role of these molecules. Moreover, the finding that aged proteins from the human eye crystallin, teeth, bone, blood vessels or the brain incorporate D-aspartic acids to specific primary protein sequences fostered the hypothesis that aging might be related to D-amino acid isomerization of body proteins. The experimental confirmation that schizophrenia and neurodegenerative diseases modify plasma free D-amino acids or tissue levelsnurtured the opportunity of using D-amino acids as therapeutic agents for several disease treatments, a strategy that prompted the successful current application of D-amino acids to human medicine.
(© 2024 The Chemical Society of Japan and Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: