A potential target for noninvasive neuromodulation of PTSD symptoms derived from focal brain lesions in veterans.

Autor: Siddiqi SH; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, MA, USA. shan.siddiqi@mgh.harvard.edu.; Department of Psychiatry, Mass General Brigham, Harvard Medical School, Boston, MA, USA. shan.siddiqi@mgh.harvard.edu., Philip NS; Center for Neurorestoration and Neurotechnology, Providence VA Healthcare System, Providence, RI, USA.; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA., Palm ST; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, MA, USA., Carreon DM; Acacia Mental Health, Sunnyvale, CA, USA., Arulpragasam AR; Center for Neurorestoration and Neurotechnology, Providence VA Healthcare System, Providence, RI, USA.; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA., Barredo J; Center for Neurorestoration and Neurotechnology, Providence VA Healthcare System, Providence, RI, USA.; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA., Bouchard H; Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA.; Department of Psychiatry, Durham VA Medical Center, Durham, NC, USA., Ferguson MA; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, MA, USA.; Department of Neurology, Mass General Brigham, Harvard Medical School, Boston, MA, USA., Grafman JH; Departments of Physical Medicine and Rehabilitation, Northwestern Feinberg School of Medicine, Chicago, IL, USA.; Department of Neurology, Northwestern Feinberg School of Medicine, Chicago, IL, USA.; Department of Psychiatry, Northwestern Feinberg School of Medicine, Chicago, IL, USA.; Shirley Ryan AbilityLab, Chicago, IL, USA., Morey RA; Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA.; Department of Psychiatry, Durham VA Medical Center, Durham, NC, USA., Fox MD; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, MA, USA.; Department of Neurology, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2024 Nov; Vol. 27 (11), pp. 2231-2239. Date of Electronic Publication: 2024 Sep 24.
DOI: 10.1038/s41593-024-01772-7
Abstrakt: Neuromodulation trials for the treatment of posttraumatic stress disorder (PTSD) have yielded mixed results, and the optimal neuroanatomical target remains unclear. Here we analyzed three datasets to study brain circuitry causally linked to PTSD in military veterans. In veterans with penetrating traumatic brain injury, lesion locations that reduced probability of PTSD were preferentially connected to a circuit including the medial prefrontal cortex, amygdala and anterolateral temporal lobe. In veterans without lesions, PTSD was specifically associated with increased connectivity within this circuit. Reduced functional connectivity within this circuit after transcranial magnetic stimulation correlated with symptom reduction, even though the circuit was not directly targeted. This lesion-based 'PTSD circuit' may serve as a target for clinical trials of neuromodulation in veterans with PTSD.
(© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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