The endocannabinoid system as a therapeutic target in neuropathic pain: a review.

Autor:	Quintero JM; Department of Clinical Pharmacology, Evidence-Based Therapeutics Group, Faculty of Medicine, Universidad de La Sabana and Clínica Universidad de La Sabana, Chía, Cundinamarca, Colombia.; Doctoral Programme of Biosciences, Universidad de La Sabana, Chía, Colombia., Diaz LE; Facultad de Ingeniería, Universidad de La Sabana, Chia, Colombia., Galve-Roperh I; Department of Biochemistry and Molecular Biology, School of Chemistry and Instituto de Investigación en Neuroquímica, Complutense University, Madrid, Spain.; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Bustos RH; Department of Clinical Pharmacology, Evidence-Based Therapeutics Group, Faculty of Medicine, Universidad de La Sabana and Clínica Universidad de La Sabana, Chía, Cundinamarca, Colombia., Leon MX; Grupo Dolor y Cuidados Paliativos, Universidad de La Sabana, Chía, Colombia., Beltran S; Faculty of Medicine, Universidad de La Sabana, Chía, Colombia., Dodd S; Faculty of Medicine, Universidad de La Sabana, Chía, Colombia.; IMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Barwon Health, Geelong, Australia.; Centre for Youth Mental Health, University of Melbourne, Parkville, Australia.
Jazyk:	angličtina
Zdroj:	Expert opinion on therapeutic targets [Expert Opin Ther Targets] 2024 Sep; Vol. 28 (9), pp. 739-755. Date of Electronic Publication: 2024 Sep 24.
DOI:	10.1080/14728222.2024.2407824
Abstrakt:	Introduction: This review highlights the critical role of the endocannabinoid system (ECS) in regulating neuropathic pain and explores the therapeutic potential of cannabinoids. Understanding the mechanisms of the ECS, including its receptors, endogenous ligands, and enzymatic routes, can lead to innovative treatments for chronic pain, offering more effective therapies for neuropathic conditions. This review bridges the gap between preclinical studies and clinical applications by emphasizing ECS modulation for better pain management outcomes. Areas Covered: A review mapped the existing literature on neuropathic pain and the effects of modulating the ECS using natural and synthetic cannabinoids. This analysis examined ECS components and their alterations in neuropathic pain, highlighting the peripheral, spinal, and supraspinal mechanisms. This review aimed to provide a thorough understanding of the therapeutic potential of cannabinoids in the management of neuropathic pain. Expert Opinion: Advances in cannabinoid research have shown significant potential for the management of chronic neuropathic pain. The study emphasizes the need for high-quality clinical trials and collaborative efforts among researchers, clinicians, and regulatory bodies to ensure safe and effective integration of cannabinoids into pain management protocols. Understanding the mechanisms and optimizing cannabinoid formulations and delivery methods are crucial for enhancing therapeutic outcomes.
Databáze:	MEDLINE
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