Evidence of time dependent degradation of polypropylene surgical mesh explanted from the abdomen and vagina of sheep.

Autor: Farr NTH; School of Chemical, Materials and Biological Engineering, University of Sheffield, Sheffield, UK; Insigneo Institute for in silico Medicine, University of Sheffield, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield Children's NHS Foundation Trust and Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust, Sheffield, UK. Electronic address: n.t.farr@sheffield.ac.uk., Gregory DA; School of Chemical, Materials and Biological Engineering, University of Sheffield, Sheffield, UK; Insigneo Institute for in silico Medicine, University of Sheffield, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield Children's NHS Foundation Trust and Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Workman VL; School of Chemical, Materials and Biological Engineering, University of Sheffield, Sheffield, UK; Insigneo Institute for in silico Medicine, University of Sheffield, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield Children's NHS Foundation Trust and Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Rauert C; Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Woolloongabba, Australia., Roman S; School of Chemical, Materials and Biological Engineering, University of Sheffield, Sheffield, UK., Knight AJ; Department of Physics and Astronomy, University of Sheffield, Sheffield, UK., Bullock AJ; School of Chemical, Materials and Biological Engineering, University of Sheffield, Sheffield, UK., Tartakovskii AI; Department of Physics and Astronomy, University of Sheffield, Sheffield, UK., Thomas KV; Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Woolloongabba, Australia., Chapple CR; Department of Urology, Royal Hallamshire Hospital, Urology Clinic, Sheffield, UK., Deprest J; Centre for Surgical Technologies, Group Biomedical Sciences, KU Leuven, Leuven, Belgium; Department of Development and Regeneration, Woman and Child, Group Biomedical Sciences, KU Leuven, Leuven, Belgium; Pelvic Floor Unit, University Hospitals KU Leuven, Leuven, Belgium., MacNeil S; School of Chemical, Materials and Biological Engineering, University of Sheffield, Sheffield, UK., Rodenburg C; School of Chemical, Materials and Biological Engineering, University of Sheffield, Sheffield, UK; Insigneo Institute for in silico Medicine, University of Sheffield, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield Children's NHS Foundation Trust and Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Jazyk: angličtina
Zdroj: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2024 Dec; Vol. 160, pp. 106722. Date of Electronic Publication: 2024 Sep 05.
DOI: 10.1016/j.jmbbm.2024.106722
Abstrakt: The failure of polypropylene mesh is marked by significant side effects and debilitation, arising from a complex interplay of factors. One key contributor is the pronounced physico-mechanical mismatch between the polypropylene (PP) fibres and surrounding tissues, resulting in substantial physical damage, inflammation, and persistent pain. However, the primary cause of sustained inflammation due to polypropylene itself remains incompletely understood. This study comprises a comprehensive, multi-pronged investigation to unravel the effects of implantation on a presumed inert PP mesh in sheep. Employing both advanced and conventional techniques to discern the physical and chemical transformations of the implanted PP. Our analyses reveal a surface degradation and oxidation of polypropylene fibres after 60 days implantation, persisting and intensifying at the 180-day mark. The emergence and accumulation of PP debris in the tissue surrounding the implant also increased with implantation time. We demonstrate observable physical and mechanical alterations in the fibre surface and stiffness. Our study shows surface alterations which indicate that PP is evidently less chemically inert than was initially presumed. These findings underscore the need for a re-evaluation of the biocompatibility and long-term consequences of using PP mesh implants.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: N.T.H.F has provided expert testimony for lawsuits concerning surgical mesh. This testimony was provided subsequent to the analysis and submission of this manuscript. J.D research program has previously received funding from Johnson & Johnson, Blasingame, Burch, Garrard and Ashley (Atlanta, GA), Clayton Utz (Sydney, Australia).
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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