A 4-week morning light treatment reduces amygdala reactivity and clinical symptoms in adults with traumatic stress.

Autor: Burgess HJ; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. Electronic address: bhelen@med.umich.edu., Rizvydeen M; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Huizenga B; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Prasad M; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Bahl S; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Duval ER; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Kim HM; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Phan KL; Department of Psychiatry, Ohio State University, Columbus, OH, USA., Liberzon I; Department of Psychiatry, Texas A&M University, College Station, TX, USA., Abelson J; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Klumpp H; Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA., Horwitz A; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Mooney A; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Raglan GB; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Zalta AK; Department of Psychological Science, University of California Irvine, Irvine, CA, USA.
Jazyk: angličtina
Zdroj: Psychiatry research [Psychiatry Res] 2024 Dec; Vol. 342, pp. 116209. Date of Electronic Publication: 2024 Sep 21.
DOI: 10.1016/j.psychres.2024.116209
Abstrakt: Trauma leads to mental health problems including posttraumatic stress disorder (PTSD), depression, and anxiety. New treatments are needed for traumatic stress that can overcome barriers to care while targeting underlying biological mechanisms of the pathology. Morning light treatment has potential as a novel intervention for traumatic stress. We conducted a randomized clinical trial testing 3 doses of a 4-week morning light treatment in people with traumatic stress to evaluate brain mechanisms underlying the treatment. Forty-six participants completed a baseline week followed by a 4-week morning light treatment (15, 30 or 60 mins each morning). Functional magnetic resonance imaging was conducted at pre- and post-treatment using an emotional faces task to probe the amygdala, based on prior work showing direct effects of light on the amygdala and the role of amygdala in traumatic stress. Clinician-rated symptoms and self-reported symptoms were also assessed at pre- and post-treatment. No group differences were observed in left amygdala reactivity, but right amygdala reactivity reduced only in the 30 and 60 min groups with medium effect sizes. Clinical symptoms reduced in all groups with medium to large effect sizes. Self-reported depression and anxiety scores reduced more in the 60 min than in the 15 min group (p = .02). The results suggest that 4 weeks of morning light treatment of at least 30 min per day can reduce amygdala reactivity and symptoms of traumatic stress. Morning light treatment should be further explored as a potential treatment for traumatic stress, given it is relatively safe, acceptable, accessible and scalable.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Helen Burgess reports financial support was provided by National Institutes of Health. Helen Burgess reports a relationship with Natrol Inc that includes: consulting or advisory. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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